molecular subtyping of sclc, as well as the trends in molecular targeting and immunotherapeutic for sclc. based on the latest sequencing data for sclc, we combined molecular subtypes with gene mutations in small cell lung cancer. this review may provide a basis for guiding the development of ...
Histological and molecular subtyping of non-small cell lung cancer (NSCLC) is important for predicting survival and drug response in these patients. Up to 8聽% of NSCLC are multifocal and these tumor foci are often clonally related. Multiple foci can however also represent different primary tumors...
Together, these results support further ETS fusion-based subtyping of disease but also reveal a greater molecular and likely biological diversity among ERG fusion-positive tumors than previously appreciated. Likewise, these results are consistent with in vivo mouse modeling and expression profiling studies...
Molecular diagnostics of a single multifocal non-small cell lung cancer case using targeted next generation sequencing Histological and molecular subtyping of non-small cell lung cancer (NSCLC) is important for predicting survival and drug response in these patients. Up to ... WRR Geurts-Giele,DVD...
(RNAseq), gene expression microarrays, or other single-molecule enumeration methods that are used to subclassify tumors into gene expression signatures. For example, gene expression arrays are used to provide consensus molecular subtyping of colorectal cancer [110]. Mutated signatures that suggest “...
Current treatment guidelines refer to small cell lung cancer (SCLC), one of the deadliest human malignancies, as a homogeneous disease. Accordingly, SCLC therapy comprises chemoradiation with or without immunotherapy. Meanwhile, recent studies have made
Warth A, Endris V, Penzel R, Weichert W (2014) Molekularpathologie des Lungenkarzinoms. Pathologe 35:565–573 CrossRef Warth A, Muley T, Herpel E et al (2012) Large-scale comparative analyses of immunomarkers for diagnostic subtyping of non-small-cell lung cancer biopsies. Histopathology...
Chemi, F. et al. cfDNA methylome profiling for detection and subtyping of small cell lung cancers.Nat. Cancerhttps://doi.org/10.1038/s43018-022-00415-9(2022). Hu, X. et al. Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas.Nat. Commun.12, 687 (2021)...
molecular subtypes, PSCCE-A and PSCCE-N, which are highly similar to SCLC subtypes. A T cell excluded phenotype is widely observed in PSCCE. In conclusion, PSCCE has genomic alterations, transcriptome features and molecular subtyping highly similar to SCLC but distinct from ESCC or EAC. These...
Molecular subtyping based on gene expression patterns has allowed researchers to develop tools for the identification of molecular events associated subtypes in various tumors such as colon, lung, ovarian and prostate cancer, and provided somewhat success in prognosis and treatment [[11], [12], [13...