synthesizing and screening the molecular glue library, structure-guided medicinal chemistry optimization, and testing in patient-derived cancer cells. It was only possible through the combined expertise of Rankovic, Fischer and Klco’s labs, in concert with internal and external collaborators...
molecular identities and tissue distribution patterns of ECMs in the mouse HF at high spatial resolution. Our study provides the comprehensive overview of the ECM landscape within the adult HF and highlights how BM composition and structure are exquisitely tailored for individual inter-tissue interactions...
Using chemoproteomic platforms, we show that members of the manumycin family of polyketides, which bear multiple potentially reactive sites, target C374 of the putative E3 ligase UBR7 in breast cancer cells, and engage in molecular glue interactions with the neosubstrate tumor-suppressor TP53, ...
(2018). Influence of membrane lipid composition on the structure and activity of γ-secretase. Physical Chemistry Chemical Physics. https://doi.org/10.1039/C8CP04138E Aguilar, Z. P. (2013). Chapter 2 – Types of nanomaterials and corresponding methods of synthesis. In Z. P. Aguilar (Ed.)...
Histone lysine methylation is pivotal in shaping the epigenetic landscape and is linked to cell physiology. Coordination of the activities of multiple histone lysine methylation modifiers, namely, methyltransferases and demethylases, modulates chromatin structure and dynamically alters the epigenetic landscape,...
In the case of fibrous proteins, their supramolecular structure is largely dependent on the mechanical function of the tissue, and is optimized for the magnitude and direction of force the tissue must handle. Many connective tissues are rich in type I collagen, including bone (~ 90% of bone ...
ProductLithium heparin Syntex manufactures a wide range of active pharmaceutical ingredients, including sodium heparin both from bovine and porcine origin, calcium heparin, lithium heparin, low molecular weight heparin and pyrogen free chondroitin for injectables. Syntex complies with GMP and exports to ...
The shell consists of the protein sericin (25–30 % of the overall fiber weight), which acts as a glue and protective coating surrounding the fibroin core (70–75 % of the overall fiber weight). The structure is generated during spinning, when fibroin nanofibrils self-assemble into silk ...
A mesh structure just inside the nuclear membrane that is composed of lamins and lamin-associated proteins. Nuclear speckles Also known as splicing speckles, these are nuclear domains enriched in pre-mRNA splicing factors and located in interchromatin regions of the nucleoplasm. Superenhancers Genomic...
Structure determination of the pentameric GPI-T complex To gain insights into the GPI anchoring process, we set to determine its 3D structure by starting with its recombinant expression. The human GPI-T subunits were co-expressed in HEK293 cells with a thermostable green fluorescence protein (TGP...