The resolved structures provide new insightinto the mechanism underlying the high constitutive activity of 5-HT1A receptors: the ligand-binding site in the structure of the 5-HT1A receptor in the apo-state is similar to the structure of theligand-binding pocket in complex with serotonin. Critical...
The electronic structure and low-energy conformations of the protonated serotonin molecule were examined by quantum mechanical and molecular mechanical calculations based on the AMBER force field. The flexibility and internal motions of the molecule, which may be important for its mode of receptor intera...
5-hydroxytryptamine (5-HT serotonin) is a neurotransmitter essential for a large number of physiological processes including the regulation of vascular and non-vascular smooth muscle contraction, modulation of platelet aggregation, and the regulation of appetite, mood, anxiety, wakefulness and perception....
(A) Hierarchical structure of the peripheral nervous system neuronal cell types. Neurotransmitters used by each cell types are indicated by the colored dots next to each leaf. (B) gt-SNE embedding of all related cells demonstrate the diversity and abundance of the different clusters. (C) Dot ...
of organogenesis at cellular resolution7. Similarly, a two-dimensional (2D) section of a whole E10 embryo was also spatially charted, defining the anatomic annotation of major tissue regions6. However, the cells in the embryo exist in a three-dimensional environment where structure, morphology, ...
A comparative study on neuronal serotonin and norepinephrine reuptake based on conformational analysis. A number of tertiary and secondary homoallylic amines, i.e. (Z)- and (E)-4-(4-bromophenyl)-4-(3-pyridyl)-3-buten-1-ylamines, were synthesized in diastereom... T Hoegberg,SB Ross,P ...
Structure-Based Discovery of Selective Serotonin 5-HT1B Receptor Ligands Rodr铆guez etal. perform large-scale docking screens against the crystal structures of serotonin 5-HT1B and 5-HT2B receptors to identify subtype-selective ... D Rodríguez,J Brea,M Loza,... - 《Structure》 被引量: ...
hydroxytryptamin, 5-HT) receptors as well as the serotonin transporter (SERT, 5-HTT), the vesicular monoamine transporter 2, monoamine oxidase type A and 5-HT synthesis in the human brain. Recent advances in in vivo quantification of these different receptors and enzymes that are part of ...
2a). A set of PACAP derivatives was then prepared, for which each of these sequence positions was replaced with a lysine-biotin residue. Fig. 2: Engineering a PACAP-based AVATar. a Identification of candidate ligand attachment sites on PACAP: Structure of PACAP in complex with a PAC1 ...
et al. Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta. eLife 5, e17219 (2016). PubMed PubMed Central Google Scholar Coleman, J. A., Green, E. M. & Gouaux, E. X-ray structures and mechanism of the human serotonin transporter. Nature 532, ...