However, it fails to identify key metastable states and fails short for non-convex cluster shapes [249]. In addition, k-means clustering is dependent on the initial centroid estimation. In the standard method of initiating centroid, k-means++, it picks a random point and picks the maximally ...
a. Flow chart of data processing for Ac-CoA-bound HGSNAT complexes. Details may be found in Methods. b. Cryo-EM densities of the transmembrane helixes in the Ac-CoA-bound HGSNAT complexes. Extended Data Fig. 3 3D reconstructions of the apo, Ac-CoA-bound, CoA/NAG-bound, and CoA/4MU...
(2009). The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9: 313–323. Schloss PD, Gevers D, Westcott SL. (2011). Reducing the effects of PCR amplification and sequencing artifacts on 16S rRNA-based studies. PLoS One 6: e27310. Segata N, ...
The structural plasticity of βarr1-GPCR complexes emerges also from the analysis of the MD trajectories of WT and mutated V2R, which expand the possible shapes of the octagonal radar charts that, in this case, plot the average values of the eight descriptors computed over the MD trajectories...
Another desired feature of active biomimetic devices is the ability to fold two-dimensional (2D) surfaces into complex 3D shapes. To accomplish this, we expanded our approach to generate a more intricate shape-morphing, such as the self-folding of a hydrogel cube from a cruciform precursor consi...
Among the 631 genes, 446 genes (71%) matched the SWISS-PROT human database, as shown in the pie chart. c Relative gene expression levels of differentially expressed genes (678 genes) at different phase of testes. CPM values were scaled to row Z-scores for each of the genes. In mature...
these are common phenomena with well-understood mechanisms. Instead, the question is which dose–response shapes should be expected for specific environmental chemicals and under what specific circumstances” (Birnbaum, 2012). The concept of nonmonotonicity is distinct ...
The structural changes in NSF during conversion into micrococoon shapes were also examined using Fourier transform infrared (FTIR) spectroscopy. The FTIR spectrum, in particular in the region containing the characteristic protein amide I bands, is highly sensitive to the secondary and tertiary structure...
RNA molecules have the potential to form highly structured macromolecules by folding into double-stranded stems, single-stranded loops and bulges, which again can fold further into three-dimensional structures, allowing for the potential formation of complex shapes. So far, the structure of only a ...
FIG. 8 is a flow chart depicting another aspect of the drug screening disclosure. DETAILED DESCRIPTION To date, a greater understanding of the biology of CRC has been gained through the research on adenomatous polyposis coli (“APC”), p53, and Ki-ras genes, as well as the corresponding pro...