Bossy-Wetzel, E., Schwarzenbacher, R. & Lipton, S. Molecular pathways to neurodegeneration.Nat Med10(Suppl 7), S2–S9 (2004). https://doi.org/10.1038/nm1067 Download citation Received27 April 2004 Accepted24 May 2004 Published01 July 2004 ...
and transgenic overexpression of α-synuclein causes neurodegeneration in mice. The molecular mechanisms involved, however, remain incompletely understood. Here we show that, in transgenic mice, α-synuclein induced neurodegeneration involves activation of the ubiquitin/proteasome system, a massive increase ...
L. Molecular pathways of neurodegeneration in Parkinson's disease. Science 302, 819-822 Parkinson's disease (PD) is a complex disorder with many different causes, yet they may intersect in common pathways, raising the possibility that neuropro... TM Dawson,VL Dawson - 《Science》 被引量: 0...
The final demise of motor neurones is likely to involve a programmed cell death pathway resembling apoptosis.doi:10.1136/JNNP.2004.048652P J ShawBMJ Publishing GroupJournal of Neurology, Neurosurgery And PsychiatryShaw P (2005), "Molecular and cellular pathways of neurodegeneration in motor neurone ...
Molecular pathways to neurodegeneration The molecular bases underlying the pathogenesis of neurodegenerative diseases are gradually being disclosed. One problem that investigators face is disting... E Bossy-Wetzel,R Schwarzenbacher,SA Lipton - 《Nature Medicine》 被引量: 1485发表: 2004年 Introduction to...
contributing to neurodegeneration conditions in the CNS. Mitochondria are the major source of intracellular ROS and antioxidant enzymes, which maintain redox balance. Neurotropic viruses causing both acute and slow infection can induce the generation of ROS, which can initiate the lipid peroxidation proce...
Molecular Neurodegeneration BioMed Central Research article Open Access The PI3K-Akt-mTOR pathway regulates Aβ oligomer induced neuronal cell cycle events Kiran Bhaskar1, Megan Miller2, Alexandra Chludzinski3, Karl Herrup4, Michael Zagorski2 and Bruce T Lamb*1,3,5,6 Address: 1Department of ...
Thus, the inhibited Aralar-MAS pathway in Aralar deficiency and in OXPHOS defects might further contribute to neurodegeneration in Parkinson disease (PD). 5. Treatment of Patients and Murine Models of AGC1/Aralar Deficiency 5.1. Treatment of AGC1-Deficient Patients with Ketogenic Diet (KD) Falk ...
The leading open access journal in the field of neurosciences, Molecular Neurodegeneration encompasses all aspects of neurodegeneration research at the ...
Spinal cord injury (SCI) disrupts both axonal pathways and segmental spinal cord circuitry, resulting in permanent loss of motor, sensory, and autonomic function. Exercise has been shown to induce synaptic plasticity and restore motor/sensory function in SCI patients.159Subsequently, endurance exercise...