Molecular Pathology: The Laboratory-Developed Testdoi:10.1016/j.yamp.2020.09.001Gregory J. TsongalisAdvances in Molecular Pathology
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street 34th St, Philadelphia, PA, 19104, USA MacLean P. Nasrallah & Mariarita Santi Department of Neurological Surgery, Northwestern University, Chicago, IL, USA Craig Horbinski Departm...
Data from fluorescence microscopy, ex vivo wide-field imaging, endoscopy, and PARP1 IHC on mice were analyzed with unpaired two-tailed t-test or one-way analysis of variance (ANOVA) followed bypost-hocTukey test or Dunnett’s multiple comparisons test. Kruskal–Wallis test with Dunn’s correct...
The choice of mouse as an additional organism supported by our database is a natural choice as it is a widely used model of human physiopathology. However, we are already planning to add new organisms in the near future. As more and more experimentally validated interactions are available, ...
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We delve into the diversity of the NPHP causing genes and discuss known molecular mechanisms and biochemical pathways that may have possible points of intersection with polycystic kidney disease (the most studied renal cystic pathology). We delineate the pathologies arising from extra-renal ...
To further evaluate the sensitivity of brain aging to AD pathology, we tested associations with other established PET and biofluid AD biomarkers, as well as measures of cognition. To test the additional utility of brain age estimates in capturing AD-related atrophy, we compared brain age to ...
All statistical analyses were conducted with SPSS version 20 software (IBM, Armonk, NY, USA). Statistical significance was calculated usingt-tests, and significance was set atP<0.05. All values are expressed as the mean± s.d. ANOVA with thepost hocBonferroni test was used for multiple group...
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