Molecular mechanisms of vitamin D action. Calcif Tissue Int . 2013;92:77–98.Haussler MR, Whitfield GK, Kaneko I, Haussler CA, Hsieh D, Hsieh JC, . Molecular Mechanisms of Vitamin D Action. Calcif Tissue Int 2012 ; http://dx.doi.org/ 10.1007/s00223-012-9619-0 ; PMID: 22782502...
New developments in our lab related to the function and regulation of target proteins have provided novel insights into the mechanisms of vitamin D action. Studies in our lab have shown that the calcium-binding protein, calbindin, which has been reported to be a facilitator of calcium diffusion,...
Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actionsCalcium and vitamin DOsteogenesis imperfectaRecent studies have suggested that vitamin D activities involve vitamin D receptor (VDR)-dependent and VDR-independent effects of 1伪,25-dihydroxyvitamin D(1,...
Here, we discuss the effect of vitamin D on immune cell maturation, differentiation and function; microbiome; genetic and epigenetic regulation (eg DNA methylation); and how these processes are implicated in food allergies.doi:10.1111/jcmm.13607...
Molecular Mechanisms of Vitamin D Action The hormonal metabolite of vitamin D, 1 alpha,25-dihydroxyvitamin D-3 (1,25D), initiates biological responses via binding to the vitamin D receptor (VDR). ... MR Haussler,GK Whitfield,I Kaneko… - 《Calcified Tissue International》 被引量: 557发表:...
This Review describes the mechanisms of action of antioxidants synthesized in vivo, antioxidants derived from the human diet and synthetic antioxidants developed as therapeutic agents, with a focus on the gaps in our current knowledge and the approaches needed to close them. The Review also explores...
However, these treatments had no effect on β-catenin signaling and proliferationWe found that VDR expression was lowered in mice with high colonic β-catenin signaling, suggesting that cancerous events may suppress VDR action. Next we examined mechanisms for suppression of vitamin D signaling. We ...
Alpha-tocopherol (vitamin E) is an essential plant lipid that scavenges free radicals in biological membranes, thereby preventing oxidative stress. In the liver, the alpha-tocopherol transfer protein (TTP) facilitates the secretion of ingested α-tocopherol to the circulation for uptake by extra ...
What is certain is that PZA is a prodrug that is converted into pyrazinoic acid (POA) by the enzyme pyrazinamidase, PncA (Rv2043c)8, and that most of the PZA clinical resistance arises from loss of function mutations in pncA. However, multiple mechanisms of action and targets have been ...
Molecular mechanisms of nutraceuticals in neurodegenerative diseases117. Full size image According to Chiu et al.117, oxidative stress is one of the molecular targets for nutraceuticals in neurodegenerative disorders. This happens with the emergence of an imbalance between the body’s ability to use an...