Additionally, genes involved in synaptogenesis are also frequently associated with neurological or psychiatric disorders, suggesting a relationship between synaptogenesis and brain physiology and pathology. Thus
Social interaction and communication are evolutionary conserved behaviours that are developed in mammals to establish partner cognition. Deficit in sociability has been represented in human patients and animal models of neurodevelopmental disorders, whic
S. Synaptic development of the cerebral cortex: implications for learning, memory, and mental illness. Prog. Brain Res. 102, 227–243 (1994). CAS PubMed Google Scholar Markus, E. J. & Petit, T. L. Neocortical synaptogenesis, aging, and behavior: lifespan development in the motor-...
Molecular Mechanisms of Synaptogenesis 作者: Alexander Dityatev / Alaa El-Husseini 页数: 524 ISBN: 9781441940902 豆瓣评分 目前无人评价 评价: 写笔记 写书评 加入购书单 分享到 推荐 我来说两句 短评 ··· 热门 还没人写过短评呢 我要写书评 Molecular Mechanisms of Synaptogenesis的书评 ··· (...
Vrljic, M. et al. Molecular mechanism of the synaptotagmin-SNARE interaction in Ca2+-triggered vesicle fusion.Nature Struct. Mol. Biol.17, 325–331 (2010) CASGoogle Scholar Rizo, J., Chen, X. & Arac, D. Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter releas...
Vaughn, J. E. Fine structure of synaptogenesis in the vertebrate central nervous system.Synapse3, 255–285 (1989). CASPubMedGoogle Scholar Oray, S., Majewska, A. & Sur, M. Dendritic spine dynamics are regulated by monocular deprivation and extracellular matrix degradation.Neuron44, 1021–1030...
Fig 1. Genome-wide molecular mechanisms of psychiatric diseases Etiopathogenesis of schizophrenia (SCZ), major depressive disorder (MDD), and alcohol use disorder (AUD) involves genome-wide alterations at all levels of informational flow from DNA to proteins/non-coding RNAs. SCZ, MDD, and AUD are...
Excitingly, mounting evidence points to convergence of these genes onto shared biological pathways [4,10,11••,12, 13, 14, 15] including neurogenesis and migration, synaptogenesis and synaptic plasticity, and activity-dependent transcription and translation (Figure 1). The hypothesis that ASD-ris...
APP undergoes rapid anterograde transport and is targeted to the synaptic sites [21,29,51,52], where the levels of secreted APP coincide with synaptogenesis [53]. The crystal structure of the E1 domain shows similarities to known cysteine-rich growth factors that it is thus termed as the ...
Neurotransmitter release mechanisms at the synapse Fast neurotransmission at synapses relies crucially on a series of membrane trafficking and signalling proteins, such as SNAREs, synaptotagmins and complexins. However, recent results have been hard to integrate into a consistent picture of how these ena...