www.nature.com/cdd Molecular mechanisms of late apoptotic/necrotic cell clearance IKH Poon1,2, MD Hulett*,1,2,3 and CR Parish*,1,3 Phagocytosis serves as one of the key processes involved in development, maintenance of tissue homeostasis, as well as in eliminating pathogens from an organism...
HIRONO S, NAKAMA T, TSUBOUCHI H: Molecular mechanisms of D-galactosamine/lipopolysaccharide-induced fulminant hepatic failure in mice and the effects of therapeutic agents. In: Trends in Gastroenterology and Hepatology: Millennium 2000. Niigata, 2001, pp 59-62....
Molecular mechanisms underlying the BIRC6-mediated regulation of apoptosis and autophagy Shuo-Shuo Liu, Tian-Xia Jiang, Fan Bu, Ji-Lan Zhao, Guang-Fei Wang, Guo-Heng Yang, Jie-Yan Kong, Yun-Fan Qie, Pei Wen, Li-Bin Fan, Ning-Ning Li, Ning Gao & Xiao-Bo Qiu Natu...
Molecular Mechanisms and Therapeutic Strategies of Tryptophan Metabolism in Glioma In glioma, tryptophan metabolism plays a crucial role in tumor progression and immune evasion through the upregulation of key enzymes like indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO). These en...
TNF-αis known to trigger ceramide accumulation.14We have recently demonstrated p53-dependent ceramide formation during etoposide-induced apoptosis of human glioma cells.22Therefore, changes in ceramide content following TNF-αtreatment were examined among cell lines with different p53 status. U87-LXSN ...
Mechanisms of chemotherapeutic drug activity, highlighting potentially important determinants of drug resistance. Abbreviations not in the text: C225, cetuximab; CE, carboxylesterase; CYP3A4/5, cytochrome P450 enzymes; DOX, doxorubicin/adriamycin; ETOP, etoposide; G, glutamate; Pt drugs, platinum drugs...
However, the adaptation of cancer cells to intrinsic or drug-induced oxidative stress leads to resistance to chemotherapeutic drugs [9]. Thus, deciphering the molecular mechanisms underlying ROS-modulated cancer chemoresistance will pave the way for targeting ROS systems as a potential therapeutic ...
Molecular mechanisms of Chloroquine and Hydroxychloroquine used in Cancer Therapy. Anticancer Agents Med Chem. 2023;23(10):1122–44. Article PubMed Google Scholar Zhang Y, Li Y, Han L, Zhang P, Sun S. SBF2-AS1: an oncogenic lncRNA in small-cell lung cancer. J Cell Biochem. 2019;120...
Enzyme mechanisms Structural biology This article is cited by Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II Tung T. Le Meiling Wu Michelle D. Wang Nature Chemical Biology(2023) Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis ...
death induced by genotoxic drugs, we tested whether the (R)-PFI-2 can synergize with doxorubicin, an inhibitor of Topoisomerase II. Indeed, we found that the depletion or inhibiting of Set7/9 sensitized human breast and lung cancer cells to doxorubicin, etoposide and cisplatin and caused ...