7. Objective:To establish a method to determine relative molecular mass and distribution of hydroxyethyl starch 130/0.4 and sodium chloride injection by size exclusion chromatography. 目的:建立凝胶色谱法由多角度激光光散射检测器和示差折光检测器联用测定羟乙基淀粉130/0.4氯化钠注射液相对分子质量及分布的方...
For this reason, it is important to investigate the effects of molecular interactions on release to better develop delivery systems with desirable release rates. In this study, the mass transfer and diffusion coefficients of three model molecules (i.e., octanol, octyl acetate, and octyl...
Here, we present the use of supervised machine learning to treat differential mobility spectrometry – mass spectrometry data for ten topological classes of drug candidates. We demonstrate that the gas-phase clustering behavior probed in our experiments can be used to predict the candidates’ condensed...
We use SCFBio (http://www.scfbio-iitd.res.in/software/drugdesign/lipinski.jsp) web tool for evaluating their Lipinski rule satisfaction of drug likeness properties (including molecular weight, number of hydrogen donor and acceptor bonds, rotatable bond, octanol/water partition coefficient or LogP...
All eigenvalues of the Hessian are positive for minima while transition states have one negative eigenvalue. The eigenvector corresponding to the negative eigenvalue describes the transition mode. Following the minimum energy path in mass-weighted coordinates (intrinsic reaction coordinate, IRC) allows ...
Molecular Cloning and Functional Expression of the Mouse Gap Junction Gene Connexin-57 in Human HeLa Cells A new mouse connexin gene has been isolated that codes for a connexin protein of 505 amino acid residues. Based on the predicted molecular mass of 57.115 k... D Manthey,F Bukauskas,CG...
different molecular size, e.g., linear polyacrylic acid passes through a membrane that retains a globular protein of the samemolecular mass. In addition, the shape of the protein changes in the vicinity of the membrane surface. Hence, the feed concentration must be kept to a minimum to ...
GAS CONDENSES TO LIQ; SOLIDIFIES TO SNOW-WHITE MASSLiquid is colorless. 2.3 Water Solubility negligible in water 2.4 Spectral Properties Index of Refraction: 1.000296-1.000298 @ 0 deg C/DRefractive index, gas 101.325 kPa n(d) at 25 deg C 1.0002732 2.5 Stability Incombustible and unreactive...
We calculated the octanol–water partition coefficients (LogP) of small molecular bases or repeating unit (neutral monomers) from polybases and used them as a quantitative measurement of molecular hydrophobicity. We plotted the sharpness of pH transition as defined by ΔpH10–90%(the pH span betwe...
(m/z)30. The fragmentation patterns of mass spectra were compared with those stored in the Wiley8 and NIST14s Library MS database (analysed 27 January 2023). The percentage of each compound was computed using the relative peak area of each compound in the chromatogram. The integration ...