应用该方法,研究人员发现,此化学探针成功的标记并富集了已知的Kglu修饰的线粒体底物,GAPDH和CPS1, 此外还发现Kglu修饰主要发生在细胞核内,并且H2A/H2B/H3/H4组蛋白上均存在大量的Kglu修饰。在对人组蛋白进行了液相色谱串联质谱分析...
Cancer Genome Atlas Research N, Analysis working group: Baylor College of M, Creighton CJ, Morgan M, Gunaratne PH, Wheeler DA, Gibbs RA, Agency BCC, Gordon Robertson A, Chu A, Broad I, Beroukhim R, Cibulskis K, Brigham, Women’s H, Signoretti S, Brown U, Vandin Hsin-Ta Wu F, Ra...
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Crosslinking mass spectrometry data {'Repository': 'ProteomeXchange Consortium', 'Dataset identifier': 'PRIDE PXD042388'} 代码表格 数据资源获取方式 Na Na 第13篇 英文标题 Single-nucleoid architecture reveals heterogeneous packaging of mitochondrial DNA 中文标题 单核oid结构揭示线粒体DNA异质性包装 基本信息...
Ion chemistry of a series of cluster compounds with Mo3Q4 and Mo3M'Q4 (Q = S, Se; M' = Cu, Co, Ni) cores containing 1,2 diphosphanes as ancillary ligands Electrospray ionization (ESI) and tandem mass spectrometry for the family of trinuclear [Mo3Q4(dmpe)3Cl3]+ and tetranuclear [...
(PD-1), T cell immunoglobulin and mucin domain-containing-3 (TIM-3), cytotoxic T-lymphocyte associated protein-4 (CTLA-4) [112], lymphocyte-activation gene 3 (LAG-3) [113], B7 homolog 3 protein (B7-H3) [114], T-cell immunoreceptor with Ig and ITIM domains (TIGIT) [115], serve ...
Size exclusion chromatography, mass spectrometry, X-ray crystallography and ChIP sequencing demonstrate that PHF13 binds chromatin in a multivalent fashion via direct interactions with H3K4me2/3 and DNA, and indirectly via interactions with PRC2 and RNA PolII. Furthermore, PHF13 depletion disrupted ...
Cells may die from accidental cell death (ACD) or regulated cell death (RCD). ACD is a biologically uncontrolled process, whereas RCD involves tightly structured signaling cascades and molecularly defined effector mechanisms. A growing number of novel no
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