Curcumin (CUR) has various pharmacological effects, but its extensive first-pass metabolism and short elimination half-life limit its bioavailability. Therefore, transdermal application has become a potential alternative to delivery CUR. To increase CUR solubility for the development of a transparent ...
Yifei Xuanfei Jiangzhuo formula, a Chinese herbal decoction, improves memory impairment through inhibiting apoptosis and enhancing PKA/CREB signal transduction in rats with cerebral ischemia/reperfusion Lin Wu, Qing-Shan Zhao, Tian-Wei Li, Hai-Yuan Li, Qing‑Bi Wang, Xin-Ya Bi, Xin-Kun Cai,...
Liuwei Dihuang, a traditional Chinese medicinal formula, inhibits proliferation and migration of vascular smooth muscle cells via modulation of estrogen receptors Yayun Zhang, Xing Qian, Xin Sun, Chao Lin, Yi Jing, Yuan Yao, Zhi Ma, Meiyu Kuai, Ying Lu, Xueyun Kong, Qi Chen, Xiang Wu, Xua...
Fig. 1. Chemical structural formula of curcumin. This review describes the effect of curcumin in aging and longevity of various invertebrate model organisms and mammals and also last progresses in the investigation of signaling pathways and regulation of longevity, assuming that the metabolic and endoc...
1.(Chemistry) of or relating to molecules:molecular hydrogen. 2.(Logic)logic(of a sentence, formula, etc) capable of analysis into atomic formulae of the appropriate kind molecularityn moˈlecularlyadv Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins ...
The survival fraction was calculated using the following formula: surviving fraction = (number of colonies formed/number of cells seeded) × plating efficiency of the control group. FACS PPZ023-induced ROS during apoptosis were examined by monitoring the cells after staining with the cell...
Network Pharmacology Combined with Bioinformatics Analysis to Texplore the Potential Mechanism of Phellodendri Chinensis Cortex Against Bladder Cancer Article 18 July 2024 Exploring the Targets and Molecular Mechanisms of Curcumin for the Treatment of Bladder Cancer Based on Network Pharmacology, Molecular...
[84] studied the interaction of curcumin with myosin in order to overcome the problems of poor water solubility, chemical instability and low bioavailability. Firstly, ultraviolet–visible absorption spectroscopy and fluorescence spectroscopy were used to obtain the information about quenching behavior, ...
These groups’ reactivity is influenced by a wide range of pharmacological activities15. The most important and well-studied α,β-unsaturated carbonyl-based compounds are the naturally occurring compounds chalcone (3), zerumbone (2), and curcumin (1), as well as their analogues and derivatives...
Here, Eq. (1) shows the total binding energy and their formula as: $${E}_{binding}={E}_{vdW}+{E}_{elec}+{E}_{desolv}+{E}_{hbond}+{E}_{tors}$$ (1) Vina Vina version 1.1.2 conducts the analysis of the ligand-receptor interaction profile. This algorithm systematically ...