It is therefore important to evaluate diagnostic test results on the basis of clinical context of the individual being tested including infection/vaccination status, presence or absence of symptoms and close contact with COVID-19 patients. A negative antigen result may need to be confirmed by an ...
In an effort to combat the spread of COVID-19 in major cities throughout Ghana, the government implemented several measures including lockdowns, border closure, and a ban on social gatherings such as weddings, funerals, and church services. These interventions were put into effect on March 30,...
its performance in detecting SARS-CoV-2 using antigen-detection rapid diagnostic tests (Ag-RDTs) has not been systematically reviewed. This study aimed to inform WHO guidelines by evaluating the accuracy of COVID-19 self-testing and self-sampling coupled with professional Ag-RDT conduct...
SARS-CoV-2 molecular testing and whole genome sequencing following RNA recovery from used BinaxNOW COVID-19 antigen self testsSARS-CoV-2SequencingCOVID-19Rapid testRT-PCRWidespread use of over-the-counter rapid diagnostic tests for SARS-CoV-2 has led to a decrease in availability of clinical ...
Chimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However, positive outcomes of this novel therapy in treating solid tumors are curtailed by the immunosuppressive tumor microenviro
and typing of antigens PorA and FetA. The most common carriage isolates were capsule null locus (cnl), accounting for 46.7%, followed by genogroups B (26.7%) and Y (13.3%). We also performed a molecular characterization of invasiveN. meningitidisisolates collected during the COVID-19 pandemi...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019 (COVID-19) severity and lethality. However, drugs that are effective against inflammation to treat lethal COVID-19 are still urgently needed. Here, we constructed ...
The persistent COVID-19 pandemic since 2020 has brought an enormous public health burden to the global society and is accompanied by various evolution of the virus genome. The consistently emerging SARS-CoV-2 variants harboring critical mutations impact the molecular characteristics of viral proteins ...
Given the shortcomings of the currently used nucleic acid detection and CT scans for the diagnosis of COVID-19, clinical laboratories should apply some immunological detection kits that target viral antigens or antibodies as soon as possible. Currently, POCT of IgM/IgG and ELISA kits for SARS-Co...
There is currently no conclusive evidence on whether SARS-CoV-2 can readily cross the blood-brain barrier (BBB) in humans, however SARS-CoV-2 antigens (such as spike protein) have been found in cortical neurons from patients who died of COVID-19 [60]. Interestingly, our findings also ...