后续对HNSCC肿瘤组织及其邻近正常组织进行免疫组化染色(IHC)和蛋白免疫印迹实验(WB),结果均显示肿瘤组织中PFKP的表达水平显著升高。此外,与人正常口腔上皮细胞(NOK)相比,人HNSCC细胞(CAL27、LIU-LSC-1、TU212)中PFKP的表达水平更高。 Impact factor: 27.7(2024) Published online:2024-7-9 研究背景 头颈部鳞状细胞...
The structure and application of antibody (fragments) for cancer therapy. Left box: IgG antibodies (150 kDa) as found in humans consist of a Fab and Fc fragment, which are linked through a hinge region. The Fc fragment consists of constant regions from the heavy chain (CH), while the ...
wielding influence over immune regulation and, thus, cancer therapy. Their function extends to the activation of immune cells, such as T cells, B cells, and NK cells, augmenting immune responses against cancer cells. However, their role is dualistic, wielding effects of both immunostimulation and...
Cancer cachexia has been identified as a negative outcome of cancer, leading to reduced physical function, tolerance to anticancer therapy, and survival rates [8,12,14]. Despite this, specific therapies for cancer cachexia are limited. Here, we describe skeletal muscle atrophy and the molecular me...
However, only a few are known to have an impact on patient outcome and thus may influence choice of therapy. Biologic and molecular factors known in this regard include the epidermal growth factor family and its receptors, markers of neuroendocrine differentiation in non-small cell lung cancer, ...
Targeted therapyThis article explores the impact of new insights in the biology of cancer on the treatment and the prevention of this disease. There are two types of targeted cancer treatment, afforded by the molecular profile of cancer. One concerns the use of agents targeted on a specific ...
国际简称:MOL ONCOL 年发文量:112 2区中科院分区 5.962影响因子 2024年SCI期刊影响因子出炉获取相关优质资源精准匹配期刊 SCI优质选题 严选服务 安全可靠 四区 质量保证 保密协议 化学工程/制药,医学 了解详情 SCI优质选题 严选服务 安全可靠 二区 质量保证 保密协议 ...
Despite the advances in cancer treatment, such as chemotherapy, radiotherapy, targeted therapy, and immunotherapy, lung cancer continues to be one of the main causes of cancer-related deaths worldwide and a major global health problem due to its low five-year overall survival rate and poor progno...
Molecular Therapy''s 2015 impact factor is 6.938.Molecular Therapy — OncolyticsMolecular Therapy—Oncolytics is an international, online-only, open-access journal focusing on the development and clinical testing of viral, cellular, and other biological therapies targeting cancer. While providing a ...
K. Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy. Expert. Opin. Ther. Targets 16, 103–119 (2012). Article CAS PubMed PubMed Central Google Scholar Roberts, P. J. & Der, C. J. Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of...