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The effect of a defective protein that retains interaction capabilities and so distorts or competes with normal proteins. PARALOGUES Homologous genes that originated by gene duplication (for example, human α-globin and human β-globin). SCHWANN CELLS ...
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Independ- ently generated data has revealed the neuroprotective role of macroautophagy through manipulation of either Atg7 or Atg5 – two different proteins essential for autophagy. Conditionally knocking out either of these genes in the central nervous system of mice leads to severe neurode- ...
Which of the following limits the use of PCR to detect and isolate genes? The sequence at the beginning and end of the DNA to be amplified must be known. Your friend works at the Centers for Disease Control and Prevention and has discovered a brand-new virus that has recently been introdu...
Indeed, mutation of either the genes encoding the PINK1 and Parkin proteins (PINK1 and PRKN, respectively) can result in the accumulation of dysfunctional mitochondria in animal and cell models [6] and is associated with juvenile onset autosomal recessive forms of Parkinson’s disease (PD; [7,8...
BMC Plant Biology volume 13, Article number: 134 (2013) Cite this article 5216 Accesses Metrics details Abstract Background Aluminium (Al) toxicity is considered to be one of the major constraints affecting crop productivity on acid soils. Being a trait governed by multiple genes, the ...
BMC Plant Biology volume 13, Article number: 134 (2013) Cite this article 5170 Accesses Metrics details Abstract Background Aluminium (Al) toxicity is considered to be one of the major constraints affecting crop productivity on acid soils. Being a trait governed by multiple genes, the ...
Drosophila melanogaster has only two MMP genes; mutations in both MMP genes have been isolated. Each mutant is larval lethal with defects in tissue remodelling. Collectively, the loss-of-function studies in different organisms point to MMPs as mediators of change and physical adaptation in tissues,...
The Class I genes consist of HLA genes, which are further subdivided into A, B and C subregions. The Class II genes are subdivided into the DR, DQ and DP subregions. The MHC-DR molecules are the best known; these occur on the surfaces of antigen presenting cells such as macrophages, ...