RNA gain of functionZNF9Myotonic dystrophy (DM) comprises at least two genetically distinct forms, both of which are caused by expansions of microsatellite repeats. Expansion of a CTG repeat in the DMPK gene leads to DM1, whereas expansion of a CCTG repeat in the ZNF9 gene causes DM2. In...
Potato (Solanum tuberosum L.), a member of theSolanaceafamily, is believed to have originated in the Andes Mountains along the Peru-Bolivia border in South America approximately 10,000 years ago (Spooner et al.2005). As the world’s third largest food crop after rice and wheat, the cultiv...
Heterosis has historically been exploited in plants; however, its underlying genetic mechanisms and molecular basis remain elusive. In recent years, due to advances in molecular biotechnology at the genome, transcriptome, proteome, and epigenome levels, the study of heterosis in vegetables has made sig...
Several cancer therapies are being developed, and given the variability of different cancer types, the goal of these therapies is to remove the invasive tu
[17]. Additionally, the response rate for trastuzumab plus pembrolizumab in trastuzumab-resistant, PD-L1-positive metastatic HER2-positive breast cancer was only 15% [18]. Atezolizumab, when combined with trastuzumab-emtansine (T-DM1), did not improve PFS and was associated with an increase in ...
Mouse anti- α-tubulin (DM1α) Sigma-Aldrich Cat# T6199; RRID:AB_477583 Rabbit anti-human p-INCENP Home-made; Salimian et al., 2011 N/A Rabbit anti-human Survivin Cell Signaling Technology Cat# 71G4B7; RRID:AB_2063948 Rabbit anti-human MCAK Duane Compton, Geisel School of Medicine at...
However, the basis of the human Forssman negativity was unsolved. Commemorating the 100th anniversary of the discovery of Forssman antigen, we initiated the exploration to decipher the basis of Forssman antigen negativity, and we have finally decoded the mystery. Results Potential molecular bases...
[170] mutations were treated with T-DM1, AZD4547, or taselisib, respectively. Unfortunately, objective response rates were low in all three groups, ranging from 0 to 9.5%. Reasons that might account for these low responses include that the patients were heavily pre-treated or the presence of...
·CUG expansion-associated spinocerebellar ataxia type 8 (SCA8) and myotonic dystrophy type 1 (DM1) in 2011 [103]. Since then, RAN translation has been investigated and detected in many microsatellite expansion-associated diseases [104] including fragile X-associated tremor/ataxia syndrome (FXTAS) ...
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