T cells exposed to persistent antigen and/or inflammatory signals in chronic infection or cancer can become 'exhausted', a state characterized by a hierarchical loss of effector functions and memory T cell properties, and by the expression of multiple inhibitory receptors. T cell exhaustion prevents...
In addition to susceptibility to infections, conventional primary immunodeficiency disorders (PIDs) and inborn errors of immunity (IEI) can cause immune dysregulation, manifesting as lymphoproliferative and/or autoimmune disease. Autoimmunity can be the prominent phenotype of PIDs and commonly includes cytope...
Acquisition and Analysis of DIA-Based Proteomic Data: A Comprehensive Survey in 2023 Ronghui Lou, Wenqing ShuiFebruary 2024 Article 100712 View PDF Article preview select article Secretome Analysis: Reading Cellular Sign Language to Understand Intercellular Communication Research articleOpen access Secretome ...
Agent-based models (ABMs)—also called individual-based models (IBMs)—for cellular systems are a class of computer models that aim to simulate multicellular dynamics, identifying the behavior of every individual cell and capturing natural spatial in homogeneities and variability b...
Remarkably, the majority of these novel functions appeared quite late in evolution, synchronized with the diversification of the eukaryal superkingdom. The distribution of GO terms in superkingdoms confirms that Archaea appears to be the simplest and most ancient form of cellular life, while Eukarya...
spatial distribution characteristics of CAFs and further dissect the cellular communication between CAFs and TME. In this study, we have delineated the landscape of CAFs in six common cancer types and described the unique functional features of these subtypes. We also analyzed scRNA-seq data of ...
to ErbB4-p38γ signaling cascade. Additionally, N-terminal containing STAT3ε and C-terminal containing STAT3ζ share overlapping homology with STAT3α [6]. However, the detailed functions of STAT3ε need further studies. In this review, we mainly focus on the progresses in research of STAT3α...
Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key mechanism of therapeutic resistance. Recen
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote tum
2b). Any shRNA subcloned by either of these methods is then compatible for concatenation in a multi-miR-shRNA transcript (Fig. 1c). Availability and requirements In accordance with the policy of the Alliance for Cellular Signaling (AfCS), all the vectors described in this study will be ...