Heat shock factor 1 (HSF1) is the critical orchestrator of cell responses to heat shock, and its dysfunction is linked to various diseases. HSF1 undergoes phase separation upon heat shock, and its activity is regulated by post-translational modifications (PTMs). The molecular details underlying ...
To address this, we used a combination of biochemical, structural, and cellular approaches to further elucidate key aspects of the functional FAK complex in S. aureus. We identified the importance of a Zn ion-binding pocket in the maintenance of the FakA homodimeric state and the formation of...