ofchangesinmassconcentrationatabiospecificinterface (Homola,2003).However,lackofahighlysensitiveanalytical methodfordetectingananalyteatlowconcentrationsisa majorimpedimenttoSPRbiosensortechnology.Toimprove thedetectionlimit(LOD)orsensitivityofSPR,AuNPshave beenusedinmanyreports(Lyonetal.,1998;Guetal.,1998; Zaya...