These data suggest that TALK-1 is an islet-restricted target for the treatment for diabetes.Nakhe, Arya Y.Dadi, Prasanna K.Jinsun KimDickerson, Matthew T.Behera, SomaDobson, Jordyn R.Shrestha, ShristiCartailler, Jean-PhilippeSampson, LeesaMagnuson, Mark A.eLife...
MATURITY onset diabetes of the youngGENETIC mutationGENETIC variationGENETIC testingGLYCEMIC controlBackground: Heterozygous pathogenic variants in HNF4A gene cause maturity- onset diabetes of the young type 1 (MODY1). The mutation carriers for MODY1 have been reported to be r...
MATURITY onset diabetes of the youngGLYCEMIC controlINSULIN therapyDIABETESSISTERSMaturity onset diabetes of the young (MODY) is a relatively young-onset diabetes mellitus with an autosomal dominant inheritance. Among these phenotypes, MODY3, caused by mutations in HNF1A, is one ...
MATURITY onset diabetes of the youngMOTHERSGENETIC mutationSYMPTOMSMaturity-onset diabetes of the young type 5 (MODY 5) is characterized by a single gene mutation in the HNF1B gene. This frequently leads to insulin resistance and presents as young-onset diabetes. Ot...
The first case of hyperosmolar diabetic ketoacidosis in a patient diagnosed with MODY 5 (maturity-onset diabetes of the young type 5) and 17q12 microdeletion syndromedoi:10.6065/apem.2346006.003MATURITY onset diabetes of the youngDIABETIC acidosisPEOPLE with diabetes...
SARS-CoV-2LITERATURE reviewsSARS-CoV-2 virus is highly infectious and may pose a threat to health and life, causing severe acute respiratory syndrome. The dynamic development of the pandemic forced the introduction of a number of modifications in the treatment of patients in em...
Given the limited research of KCNJ11‐MODY, we aimed to analyse its phenotypic features and prevalence in Chinese patients with early‐onset type 2 diabetes (EOD). Design, Patients and Measurements: We performed next‐generation sequencing on 679 Chinese EOD patients to screen for KCNJ11 ...
UltrasoundWater immersionObjectiveIn comparing the repeatability of the internal diameter and hemodynamic parameters of the dorsalis pedis artery measured by immersion ultrasound and contact ultrasound, the factors affecting the accuracy and repeatability of measurement were analyzed. Th...