ALS-causative mutations in FUS/TLS confer gain and loss of function by altered association with SMN and U1-snRNP. Nat. Commun. 6, 6171 (2015). ADS CAS PubMed PubMed Central Google Scholar Mirra, A. et al. Functional interaction between FUS and SMN underlies SMA-like splicing changes in...
Mutations infused in sarcoma (FUS)lead to amyotrophic lateral sclerosis (ALS) with varying ages of onset, progression and severity. This suggests that unknown genetic factors contribute to disease pathogenesis. Here we show the identification of muscleblind as a novel modifier of FUS-mediated neurodeg...
Let vi and vj represent any two row vectors of the matrix in (17). The angle between them cos(θiv,j) = vi · vj vi vj u1(di) u1(dj) + . . . + u(ndui) u(nduj) + u1(di) u1(dj) + . . . + un(dui) un(duj) = ∆u + ∆u2 2 . (19) Note that the angle ...
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