The face of oncology is rapidly changing, with the increased use of genetic profiling for the identification of critical targets involved in the hallmarks of cancer. The development of novel therapeutics, particularly those targeting key molecular pathways, will require systematic and rational planning ...
The Pharmacologic Audit Trail (PhAT) is a drug development framework that can be used to link biomarkers for rational decision-making in early phase clinical trials of novel antitumor therapeutics [7],[8]. The PhAT incorporates a step-wise process, starting with the identification of patients who...
Epigenetic analysis could also allow the identification of specific BM hallmarks. Therefore, Karlow et al. analyzed the methylation profile of BMs, comparing matched ‘trios’ of specimens retrieved from a series of 12 patients with lung adenocarcinoma and including lung normal tissue, lung primary ...