Modern drug discovery and development. In: Robertson D, editor. Clinical and Translational Science: Principles of Human Research. Academic Press; London: 2009. pp. 361–380.Alexander JC, Salazar DE. Modern drug discovery and develop- ment. In: Robertson D, ed. Clinical and translational science: prin- ciples of human research. London,...
Dr. Carolina Cavalieri Gomes from the Universidade Federal de Minas Gerais in Brazil, discusses her team’s discovery of CTNNB1 (beta-catenin) exon 3 mutations in 4 of 9 primary cases and 2 additional recurrences. While the occasional presence of ghost cells keratinization was the feature that...
4.14.4.11.1 Intuition and serendipity in drug discovery and development Pharmaceuticals have probably the most important share among bioactive molecules whose design is attempted. This impacts even on the term drug design, which is often used as a synonym of molecular design if we are targeting mol...
Using systems like Natural Language Processing, Machine Learning, and deep learning algorithms, its impact is greatly felt, especially in domains such as; illness detection and patient care improvement, forecasting and epidemic prevention, medication discovery and development, personalizing and optimizing ...
Cancer immunotherapy has been emerged as a promising strategy for treatment of a broad spectrum of malignancies ranging from hematological to solid tumors. One of the principal approaches of cancer immunotherapy is transfer of natural or engineered tumor
Drug development Many biotech and pharmaceutical companies now use AI to aid drug discovery. Drug discovery involves complex processes at all steps, such as predicting chemical properties, identifying molecules, and image analysis. For example, drug discovery research usually requires hundreds of laborator...
2.2). The novel begins when the protagonist, a drug addict, wakes up in a hotel next to the dead body of a blonde twenty-two-year-old lounge singer with whom he had injected heroin the night before. On the first page of the novel, he sees her body without immediately realizing she ...
The wind and sun are important sources of renewable energy around the world. Wind energy conversion to electric power is achieved by wind energy turbines connected to electric generators. The intermittency characteristic of the wind makes smart grid development essential to bring the energy to the po...
Paroxysmal nocturnal hemoglobinuria was shown to be a complement-mediated disease; treatment of this disease with the complement inhibitor Eculzimab/Soliris was approved by the European Medicines Agency in 2003 and by the United States Food and Drug Administration in 2007....
Currently available medications for malaria chemoprophylaxis are efficacious but the problems of patient compliance, the advance of parasite drug resistance, and real or perceived serious adverse effects mean that new chemical compounds are needed. ...