Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease. Sleep Med 2017;30:36- 42.Moderate-to-severe obstructive sleep apnea is associated with cerebral small vessel disease. Song TJ,Park JH,Choi KH,Chang Y,Moon J,Kim JH,Choi Y,Kim YJ,Lee HW. Sleep ...
Using a motorized pullback device, cross-sectional images are generated throughout the vessel length, enabling precise quantification of atherosclerotic disease burden. This study, the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial, measured the rate of disease progression in ...
Renal dysfunction is a common comorbidity in patients with MM, as excess monoclonal light chain production associated with the disease often leads to kidney complications. In the relapsed setting, the overproduction of the involved free light chain may lead to cast nephropathy, which may or may ...
Evaluating retinal vessel caliber enables exploration of the effect of improving microcirculation with statins. We investigated whether rosuvastatin therapy improves retinal vasculature in hypercholesterolemic patients with a low-to-moderate risk of coronary artery disease (CAD). This was a prospective, ...
From the standpoint of disease intervention, the up-regulation of IL-6 by SMF at first seems to be unwanted because IL-6 is generally maintained at low levels in healthy tissue [50]. Moreover, chronically elevated levels of IL-6 are usually deleterious (for example, inflammation and unabated...
Cerebral white matter hyperintensities (WMHs) are regarded as typical MRI expressions of small-vessel disease (SVD) and are common in hypertensive patients. Hypertension induces pathologic changes in macrocirculat... I Heliopoulos,D Artemis,K Vadikolias,... - 《Cardiovascular Psychiatry & Neurology...
Using this approach, a total of 48 patients were classified as having functionally significant CAD: single-vessel disease was seen in 24 patients, 16 had double-vessel disease, and 8 had triple-vessel disease. Left main disease was found in 5 of these patients. CTDE performance for ischemic ...
Li H, Förstermann U 2000 Nitric oxide in the pathogenesis of vascular disease. J Pathol 190:244 –254 35. Moncada S 1997 Nitric oxide in the vasculature: physiology and pathophysiology. Ann NY Acad Sci 811:60 – 69 36. Vapaatalo H, Mervaala E, Nurminen ML2000 Role of endothelium ...
A laminar, pulsatile shear pattern in conduit arteries mainly presents as blood flow in the anterograde direction but increased retrograde flow patterns may manifest from increased vascular tone in the downstream resistance vessel18. This is commonplace in advanced age, obesity, and hypertension15,19,...
Considering the adverse effects that obesity has on vascular hemodynamic and cardiovascular structure and function, not surprisingly, obesity has a strong malignant impact on multiple cardiovascular disease risk factors, including endothelial dysfunction, carotid artery intima-media thickening, increased arterial...