BU days had a strong correlation with Mayo stool frequency subscore and IBDQ, and moderate correlation with Mayo endoscopic subscore, rectal bleeding subscore, faecal calprotectin levels, and high-sensitivity C-reactive protein levels (Table 2). CONCLUSIONS. A high prevalence of BU (>80%) was ...
AbbVie (NYSE: ABBV) today announced the European Commission (EC) approved RINVOQ® (upadacitinib 45 mg [induction dose] and 15 mg and 30 mg [maintenance doses]) for the treatment of adult patients with moderately to severely active ulcerative colitis...
Patients are asked to self-report their stool frequency score (SFS; 0–3) and rectal bleeding score (RBS; 0–3) q4wk into an electronic data capture system (EDC). Quality of life (QoL) scores are spontaneously reported by Short Health Scale (SHS) at baseline and end of induction. ...
Indeed, HIV infection has been shown to play a significant role not only in the burden and associ- ated mortality of MSD, but also in the etiology and epi- demiology of diarrheal disease among children in Manhiça [48]. In this respect, in settings such as Man- hiça with a high...
The primary end point was the proportion of patients in remission, UC disease activity index of less than or equal to 1, with a score of 0 for rectal bleeding and stool frequency, and at least a 1-point reduction from baseline in sigmoidoscopy score. The proportions of SPD476 and placebo...
Background: As the microbiome plays an important role in instigating inflammation in ulcerative colitis (UC), strategies targeting the microbiome may offer an alternative therapeutic approach. The goal of the pilot trial was to evaluate the potential eff