Given this situation, our review summarizes recent advances in the study of gut-microbiota-mediated drug metabolism and showcases techniques and models developed to navigate the challenges posed by the microbial involvement in drug action. Therefore, we not only aim at understanding the complex ...
Humanized liver TK-NOG mice with functional deletion of hepatic murine cytochrome P450s as a model for studying human drug metabolism Shotaro Uehara , Yuichi Iida & Hiroshi Suemizu Article 01 July 2022 | Open Access Cardiovascular changes after pneumonia in a dual disease mouse model Benjam...
et al. Defining human pathways of drug metabolism in vivo through the development of a multiple humanized mouse model. Drug Metab. Dispos. 43, 1679–1690 (2015). References 217 and 227 describe humanized mouse models and chimeric mice with value to study human drug metabolism. CAS PubMed ...
In this chapter, we review many of these cellular models as tools to study the hormonal regulation of bone metabolism. In particular, we pay special attention to new human bone cell models, since these have the greatest relevance to osteoporosis research and drug discovery. These new models ...
endorphins, and many other chemicals in the body. Pain also increases heart rate, stroke volume, cardiac output, and leads to shallow fast breathing, etc. [9]. Proper use of analgesics can substantially prevent these effects and produce good data; (2) Direct physiologic effect of the drug ...
Then we discussed the clinically applicable DILI assessment markers and the importance of liver zonation in the next generation organoid- based DILI models. 展开 关键词: Drug metabolism DILI organoids hepatoxicity liver cytochrome.年份: 2023
metabolizing enzymes in the liver and small intestine, allowing one to study better the role of a particular enzyme in the metabolism and toxicity of a drug. However, since only one or two enzymes can be expressed, the complex metabolism of drugs in vivo cannot be reflected at an overall ...
Therefore, organoids are great models for investigation of organ formation and regeneration, organ homeostasis, human development and disease mechanisms as well as for drug discovery and sensitivity test, having great potentials in personalized medicine. To highlight recent progress on organoids ...
This demonstrates the ability of the VAE to integrate heterogeneous data but also that substantial confounding factors can influence the latent representation. Extracting drug to clinical and multi-omics associations We then investigated if the model had learned associations between the clinical, drug and...
the mouse [37]. Rat is extensively used as a suitable animal model for understanding the metabolic profile and pathology involved in different stages of type 2 diabetes [38]. A number of experimental mice and rat models are employed in the study of diabetes (Table1) and are discussed below...