Centenarians are a group of individuals exhibiting extreme longevity, who are characterized by a remarkable compression of morbidity. Therefore, centenarians have been postulated as a model of healthy aging. Different approaches have been used to decipher the biology and genetics of centenarians in ...
Different types of in vitro CAVD models. The most straightforward, but challenging, approach is to isolate calcified aortic valves from CAVD patients or animals. Alternatively, healthy valves can be induced using osteogenic medium. VICs and VECs are more common cell types used for in vitro CAVD ...
W. et al. Transcriptome of human foetal heart compared with cardiomyocytes from pluripotent stem cells. Development 142, 3231–3238 (2015). Google Scholar Dworatzek, E., Baczko, I. & Kararigas, G. Effects of aging on cardiac extracellular matrix in men and women. Proteomics Clin. Appl....
Despite her fame and success, Miller remained grounded and devoted much of her time to philanthropy. She has been involved with the USO, the American Cancer Society, and the Pedigree Adoption Drive, among other charitable organizations. Furthermore, she used her platform to advocate for healthy ...
of age in AD+mice (an early-symptomatic age) in four out of the five conditions of light intensities (Fig.1h,i; extended data in Fig.S2a–c). While WT mice had a constant % alternation with aging, AD+mice exhibited substantial reductions in % alternation that progressed with aging, ...
Together, these studies have reinforced investigations using cell lines and rodent models which demonstrate cellular toxicity resulting from pathological spread in AD. Synaptic loss and calcium imbalance in healthy human neurons in response to AD-associated aggregates may hint at early pathological mechanis...
(Fig.1a). In the healthy joint, these components provide support to the joint. The meniscus (not shown in Fig.1a) provides several functions including load bearing and shock absorption in the knee joint. It is a fibrocartilage composed mainly of water, type I collagen, and proteoglycans (...
most frequently the repeated assessments were related to the aging of the individual, whereaijis the age of individualjat timei. Note that other definitions of time can be specified (e.g., occasions of measurement, assessment trials in a laboratory experiment, hours of the day when studying a...
Neuroprotective, anti-inflammatory, and remyelinating properties of androgens are well-characterized in demyelinated male mice and men suffering from multiple sclerosis. However, androgen effects mediated by the androgen receptor (AR), have been only poo
The Research Council of Norway (E.F.F., grant nos. 262175 and 277813); Center for Healthy Aging, University of Copenhagen; the European Research Council (ERC—GA695190—MANNA, ERC—GA737599 —NeuronAgeScreen); the European Commission Framework Programmes; the Greek Ministry of Education (N.T...