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The U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA) have both established industry guidelines for premarketing clinical and/or nonclinical evaluation of DILI. Nonetheless, there has been limited progress in confronting the regulatory obstacles created by the adverse dru...
This paper reviews the existing bottom-up energy system models applied at island level. The aim of the paper is to answer the following research questions: i) which energy system models are mostly used at island level? ii) Are national scale models also used for island applications? If yes,...
European Medicines Agency Guideline on clinical investigation of medicinal products in the treatment or prevention of diabetes mellitus CPMP/EWP/1080/00 Rev. 1 https://www.ema.europa.eu/en/documents/scientific-guideline/guideline-clinical-investigation-medicinal-products-treatment-prevention-diabetes-melli...