The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids — which are ste
Using this model organism, age-associated changes as well as the underlying cellular and molecular processes can be investigated in depth, in order to understand and more efficiently tackle neurodegenerative events. Over the years, the visual system has become a powerful tool to investigate the ...
The moss Physcomitrella patens is now often used as a model system in plant molecular biology. ts short life cycle, easy to culture, transformant analysis and allele replacement make it an excellent material for studying plant molecular biology. Some gene targetings have succeeded and the function...
The Diptera as a Model System in Cell and Molecular Biology11This paper is dedicated to the memory of Dr. Martin Hagopian, our colleague and friend, who originally recognized the value of a comprehensive review on dipteran systems to c...
The zebrafish as a model visual system The zebrafish has bacome an important vertebrate model in developmental neuroscience because it is a useful model for embryology, developmental biology, an... J Bilotta,S Saszik - 《International Journal of Developmental Neuroscience》 被引量: 229发表: 2002年...
Conclusions The practical aim of our proposed classification scheme is to make the analysis of explicitly time-dependent transient behaviour tractable, and to encourage the wider use of non-autonomous models in systems biology. Our method is applicable to a large class of biological processes.Back...
Biochemical indicators of whole-body gamma-radiation effects in the pig Purpose: Validation of the pig as an experimental animal model for dose assessment after ionizing irradiation. Materials and methods: The evolution of haem... DONNADIEU-CLARAZ,M. - 《International Journal of Radiation Biology》...
In the present work, we have applied this approach for simulating the evolution of a biofilm, and as far as we know it is the first time this is applied to the field of biology. This is a central point of this paper. The IIM has been implemented since it offers an efficient approach...
Reuse of mathematical models becomes increasingly important in systems biology as research moves toward large, multi-scale models composed of heterogeneous subcomponents. Currently, many models are not easily reusable due to inflexible or confusing code, inappropriate languages, or insufficient documentation...
In biology, the system to be modelled is often only partially known and the distinction of relevant and irrelevant features and variables can be difficult4,5,6,7,8. But, even if the major components of a biological system are well known, the sheer complexity of the system might prevent ...