To study the in vivo function of a gene or its encoded protein and identify its role within cellular processes. Research on human diseases To mimic human diseases for the research on pathogenesis, development processes, related gene-regulation processes, therapeutic treatments, etc. To allow focused...
The animal model of CTX-induced POF is simple in operation, is short in cycle, and only needs a single dose. TG exists a killing effect on rapidly proliferating cells (such as ovarian follicle cells), the mechanism of which mainly leads to DNA base mismatch and DNA chain rupture. The ...
Due to ethics issues and limited donor menisci, especially normal control menisci, it is nearly impossible to conduct research on meniscal degeneration directly in humans, and appropriate animal models are required. Previous studies have often used small animals such as guinea pigs, rats, and rabbits...
The power-law exponent is calculated as the slope of the creep compliance over time on the log–log coordinate. The second was a cyclic loading condition aimed to characterize the complex modulus of the cell in the frequency domain. The power-law exponent is calculated as the slope of the ...
After resuspending in 300 μl PBS, cells were analyzed within 20 minutes on a FACScan cell analyzer (Becton Dickinson, Heidelberg, Germany) using fluorescence 1 (FL-1) or fluorescence 2 (FL-2) for specific immunolabeling. The Becton Dickinson Cellquest program was used for dual- and single-...
Creating a model animal cell can be an exciting and informative project. Using recycled materials is one way to turn trash in to a great project while encouraging students to use their imaginations. Using unusual materials to represent the parts of an animal cell adds a unique perspective to ea...
Fulfilling your diversified requirements on the generation of xenograft tumor models using humanized mouse cell lines, reporter cell lines, and more. Learn more We provide one-stop animal model services aimed at accelerating translational studies of life science and medicine. ...
Depression is a complex mental health disorder that is difficult to study. A wide range of animal models exist and for many of these data on large-scale gene expression patterns in the CNS are available. The goal of this study was to evaluate how well an
We, therefore, treated a panel of human myeloma cell lines (HMCLs, n = 9) with the small molecule GCN2 inhibitor, GCN2iB44, to assess whether myeloma cells rely on the ISR-GCN2 pathway for survival. This analysis revealed that treatment with GCN2iB has anti-myeloma activity, but ...
Lipoproteins are separated based on their size dependent migration differences in this assay (HDL-fast, LDL-slow and VLDL –intermediate migration). In addition, the requirement of small sample volumes, allows us to analyze the lipoprotein profile of the same animal at multiple time points. As ...