50 A particular challenge in the development of selective, adenosine triphosphate (ATP)-competitive small-molecule kinase inhibitors is the high degree of structural homology evident in the conserved ATP binding domains. For example, the ALK3 kinase domain possesses 66% sequence identity with that of...
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What advantages does the VSEPR model of chemical bonding have compared with Lewis formulas? How would polyethylene have the VSEPR shape of the tetrahedral ? What is the VSEPR of NF_4^+? Using VSEPR theory, predict the electron pair geometry and molecular shape for each molecule. (a) HOBr (...
The Z-average size of the nanoparticles was measured using DLS (Malvern Zetasizer Ultra). Prior to measurement, the nanoparticle suspensions were diluted in deionized water or ECGM (PromoCell, Germany). The samples were equilibrated before each measurement. The DLS measurements were performed in tri...
repel a stationary magnet. In the Meissner effect, screening currents develop in the superconductor even in a constant magnetic field. The superconducting material itself acts like an electromagnet with opposite polarity to that of the external field. The material is said to exhibit perfect ...
More recently, a novel culture method was published by Sampaziotis and colleagues16, to expand primary cholangiocyte-like cells as organoids by stimulation of the non-canonical Wnt signaling of the planar cell polarity pathway. These organoids retained many biliary characteristics in culture and ap...
Baicalein (BA) is a flavonoid with wide-ranging pharmacological activity. However, its biological evaluation is hampered by its low solubility in aqueous m
remains, at present, too preliminary. Another ASC lineage in sponges are the choanocytes, the progenitors of both somatic cells and gametes and the most actively proliferating cell type in these animals [164]. Choanocytes are specialized epithelial cells, responsible for the movement of water ...
Furthermore, it has been shown that switching between proton-transfer (PT) fluorescence and CT fluorescence of such 3HF derivatives depends on solvent polarity and intermolecular (solute–solvent) hydrogen-bonding perturbations of the internal hydrogen-bond of the molecule [20], [21]. In ...
Intestinal epithelial barrier is affected by multiple factors, such as tumour necrosis factor-α (TNF-α). Plasma concentration of TNF-α is higher in patients with Crohn’s disease (CD) than healthy controls (HC) and correlates positively with disease a