One Model for Protein Recognition of B-DNA Sequences Suggested by the Structure of Catabolite Gene Activator Proteindoi:10.1016/B978-0-12-501650-6.50015-8T.A. SteitzD.B. McKayI.T. Weber
In the eight years since we last examined the amino acid exchanges seen in closely related proteins, ' the information has doubled in quantity and comes from a much wider variety of protein types. The matrices derived from these data that describe the amino acid replacement probabilities between...
Therefore, we synthesized a model docosapeptide, 2, corresponding to the sequence of 1 but containing arginine rather than leucine at position 10 in the hydrophobic region of the α helix to assess the role of the alcohol function of cholesterol in protein--cholesterol interactions. The results ...
一篇利用diffusion模型——LatentDiff,在隐空间,生成蛋白多构象的文章。该文做的是粗粒度生成,生成的是 Cα 原子的坐标。 文章链接:A Latent Diffusion Model for Protein Structure Generation 1. Abstract 蛋白质是复杂的生物分子,并且在生物体内发挥重要的功能。设计和生成新颖的蛋白质能够为未来许多合成生物学应用铺...
To perform these functions, it has been suggested that protein E can form a membrane destabilizing transmembrane (TM) hairpin, or homooligomerize to form a TM pore. Indeed, in a recent study we reported that the α-helical putative transmembrane domain of E protein (ETM) forms several SDS-...
2008. Protein value of a new genotype oat (CDC SO-I) for the NRC dairy model: Protein degradation balance and kinetics, protein fractions and total metabolizable protein supply. Can. J. Anim. Sci. 88: 507-513. Recently, a new genotype of oat has been developed specifically for feed ...
Those difference explained the stability of the capsid. They has found that a triplex fits between hexamers and pentamers at quasi-three-fold positions to cement the capsid together, and six copies of the small capsid protein VP26 form a ring on the top of the hexon to stabilize the capsid...
Protein design aims to build novel proteins customized for specific purposes, thereby holding the potential to tackle many environmental and biomedical problems. Recent progress in Transformer-based architectures has enabled the implementation of languag
Pretrained neural network models for biological segmentation can provide good out-of-the-box results for many image types. However, such models do not allow users to adapt the segmentation style to their specific needs and can perform suboptimally for te
Suppression of proteolipid protein rescues Pelizaeus–Merzbacher disease Article 01 July 2020 Introduction Over 150 kinds of glycosylphosphatidylinositol (GPI)-anchored protein (GPI-AP) are expressed on the surface of mammalian cells1. GPI-APs have a variety of roles, including acting as hydrolytic ...