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Here, we introduce a language model for 5′ UTR, which we refer to as the UTR-LM. The UTR-LM is pretrained on endogenous 5′ UTRs from multiple species and is further augmented with supervised information including secondary structure and minimum free energy. We fine-tuned the UTR-LM in ...
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Gramsbergen3, Eli Gunnarson6, Anita Aperia6, Martin Lauritzen5,8, Kate L. Lambertsen3, Poul Nissen2,7,9 & Karin Lykke-Hartmann1,2,10 Migraine is a complex brain disorder, and understanding the complexity of this prevalent disease could improve quality of life for ...
Such approaches enhance confidence in the predictive validity of animal models for complex human diseases. The BTBR inbred mouse recapitulates the three core behavioral features that define ASD, including deficits in social interactions as juveniles and adults, unusual vocalizations as infants, and ...
demonstrated that partial eNOS deficiency exacerbated behavioral dysfunction, Aβ brain deposition, and microglial pathology in APP/PS1 mice, further implicating endothelial dysfunction in the pathogenesis of AD. The present findings also provide the scientific basis for developing preventive and/or therapeut...
. The protocol included laparotomy for 15 min (trauma), hemorrhagic shock (blood withdrawal to reduce the mean arterial pressure to 35 mmHg) for 75 min and resuscitation by re-infusion of all the shed blood plus lactate Ringer for 90 min. Intravenous quercetin (50 mg/kg) or vehicle were ...
Teachers, on the other hand, explain that they sometimes have the feeling, when pupils use other languages, that they do so to hide information from the teacher (they talk about something else than the lesson), or are even insulting adults and their fellow pupils [48]. If, on the other...
the gills were processed into a 10% tissue homogenate and centrifuged at 3000×gfor 15 min to collect the supernatant. Superoxide dismutase (SOD) activity, catalase (CAT) activity, malondialdehyde (MDA) content and Na+/K+-ATPase (NKA) activity were determined through the corresponding kits of ...
International Journal of Molecular Sciences Article MicroRNA-24 Attenuates Neointimal Hyperplasia in the Diabetic Rat Carotid Artery Injury Model by Inhibiting Wnt4 Signaling Pathway Jian Yang 1,*,†, Zhixing Fan 2,†, Jun Yang 1, Jiawang Ding 1, Chaojun Yang 2 and Lihua Chen 3 1 ...