Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder, which is characterized by cognitive deficit due to synaptic loss and neuronal death. Extracellular amyloid β plaques are one of the pathological hallmarks of AD. The autophagic lysos
Dry cell weight (DCW) for mircrotiter plate-based BioLector (BL) cultivations was determined using 800 μl of a well-mixed culture suspension, which was poured on pre-dried and pre-weighted spin down filter tubes (cellulose-acetate membrane; cut-off 0.2 μm; Corning). The supernatant was ...
We were interested in whether delayed administration of metformin had an effect on the numbers of microglia in the EAE model (Fig. 5D–F) based on previous work showing microglia modulation with delayed metformin delivery following brain ischemia (Livingston et al., 2020). There was an overall ...
PCR-based cloning of Cctra2 Two primers based on the sequence of FC1744, Tra2-26f (5'- tcaatcagcggtagcttgtg-3') and Tra2-939r (5'-acgtgtgttt- gtttgtttgct-3'), were used to amplify the sequence of the putative Cctra2 gene from genomic DNA isolated from the ISPRA strain. ...
The severity of chronic pancreatitis was further semi-quantitatively analyzed based on the criteria for CPI with sum of extent or areas of loss of acini, inflammatory cell infiltration and intensity of stromal fibrosis. As shown in Figure 3D, compared to caerulin induced chronic pancreatitis mice...
This technique, designed to reduce the size of the target population, is based on the release of sterile males that compete for wild females. Indeed, the medfly was the first non-drosophilid organism to be transformed [4], with the goal of introducing genes capable of improving genetic ...
this would bring a significant reduction of computational cost. The cost reduction would allow adopting optimization algorithms based on CFD simulations to improve airfoil design at a low Reynolds number. This fact would have an impact on the performance of micro aerial vehicles, but it would also...
Ultimately, additional sequence data and analysis of deletion breakpoints should allow for a more accurate discrimination of micro- and gross deletions based on the underlying mechanism. Not all deletions in Artemis were solely associated with TEs. A recurrent deletion of exons 1–3 was associated ...
Based on the symmetrical primary hydraulic fracture model, the sensitivity of critical parameters in the mathematical model to permeability and gas production is analyzed, including adsorption parameters, mechanical parameters, and hydraulic fracture geometry. On this basis, the discrete fracture network ...
Based on electrostatic (Etot) and desolvation (Esol) energies, fifty different structures were predicted. The most stable- docked structure was displayed with Chimera software. According to this analysis, we found that cinnamic acid docked in the interface of LBD of PPARα as shown in (Fig. 2E...