ventricles was visible in 12-month-old homozygousAppNL-G-Frats compared with WT littermates (Fig.5e; Supplementary information, Fig. S7c, d). Surface-rendered 3D reconstructions of the ventricle system were performed with the segmented MRI images of representative WT and homozygousAppNL-G-Frats...
Large language models (LLMs) are widely adopted tools for synthetic text generation, finding applications in language-based assistants, code generation, writing support and various other domains. As LLMs advance in quality, coherence, coverage and expertise, it can become difficult to distinguish synt...
65Dn,Dyrk1a+/+/− offspring with two copies of Dyrk1a on an otherwise trisomic mouse, DYRK1A levels were significantly reduced relative to Ts,Dyrk1a+/+/+ mice in the cerebellum (p = 0.024; d = 1.21), and the Ts,Dyrk1a+/+/− levels were comparable to Eu,Dyrk1a+/+ littermates...
作者: S Dathathri,A See,S Ghaisas,PS Huang,R Mcadam,J Welbl,V Bachani,A Kaskasoli,R Stanforth,T Matejovicova 展开 摘要: Large language models (LLMs) have enabled the generation of high-quality synthetic text, often indistinguishable from human-written content, at a scale that can ...
Microbiome (2024) 12:216 Page 15 of 18 the total DNA preparation was checked using a Thermo NanoDrop 2000 UV microphotometer and 1% aga- rose gel electrophoresis. The V3–V4 region of the bac- terial 16S rRNA gene was amplified using the primer pair 338F (5′-ACTCCTACGG GAG...
Mice were on a C57Bl/6 J background and were housed under a 12-h light-dark cycle (lights on at 7 am) with free access to food and water and with up to five littermates. To generate mice with hemizygous Loa mice (Dync1h1−/Loa) a 3-step breeding program was carried out (...
2010). This approach has shown some success in the limited context of short-term hindcasts of interannual MOC variability (Matei et al. 2012). Despite these encouraging results, the time interval required to spin-up the ocean to states accurate enough to act as viable initial conditions for ...
cerebellar RNAs fromATXN2Q127and BAC-Q72 mice compared to wild-type littermates (24 weeks of age;n = animals per group). Gene expression levels were normalized toActb Full size image Next, we tested whether increased STAU1 was a direct consequence of mutations in ATXN2 or TDP-43. ...
and 48 h using the LIVE/DEAD BacLight Kit (Thermo Fisher Scientific Cat# L7012) in combination with flow cytometry64. Briefly, according to the manufacturer’s instruction, microbial cells were washed and diluted in 0.85% NaCl saline buffer. Then, the bacteria were stained with PI and SYTO...
Andrea Bacchiocchi: Conceptualization, Methodology, Writing – original draft, Formal analysis, Data curation, Software. Gian Italo Bischi: Methodology, Formal analysis, Software, Supervision, Visualization, Resources. Germana Giombini: Conceptualization, Methodology, Writing – original draft, Writing – ...