In addition, knowledge about the distribution of outcomes on the training and testing sites can allow for accurate assessment of model performance, as AUROC is an uninformative marker for heavily imbalanced datasets, where the precision-recall curve can be more informative61. Even if performance ...
Connecting the GM to the PC 1 Check whether the BT LED in the GM status display area is on. If the LED is off, hold down the GM USER1 key for at least 3 seconds. The BT LED in the GM status display area is turns on, the GM enters the connection standby state. BT LED 2 ...
that the inferred differentiation time correlated well with the transition of structures from day 4 to day 8 post-aggregation. These data, in combination with canonical marker expression, enabled us to annotate the cell types in our human embryo-like structures (Fig.3b, Extended Data Fig.5e,fan...
Schizosaccharomyces japonicusandSchizosaccharomyces pombeexhibit divergent mitotic programs.Left: LiveS. pombeandS. japonicuscells expressing the endoplasmic reticulum marker GFP-ADEL and the nucleoplasmic protein Nhp6-mCherry. Note a considerably larger cell size inS. japonicus. Scale bar5 μm.Right: Sche...
Classic GC methods rely on adjusting all marker-trait associations in the same way, which ignores the strength of the relationship between the genealogy of the genetic marker under study and the (hidden) pedigree structure, and thus also dependencies between markers. The basic idea of MM for ...
avg_y, marker='*', color='black', s=300) plt.title("Reduced Dimension: Embeddings visualized ...
To determine if overtMSNloss occurs in HdhQ200/200 mice at 8 months of age, we measured expression of DARPP-32 in the dorsal striatum of wild-type and HdhQ200/200 mice, as this protein is a dopamine- and cAMP-regulated neuronalphosphoproteincommonly used as a marker of MSNs (Svenningss...
ZZ- and RR-HLCs were transfected with the ER marker, green fluorescence protein (GFP)-KDEL, that has been shown to co-localise with A1AT polymers.9 Transfections of HLCs with the GFP-KDEL construct yielded a population of RR-HLCs which all contained normal, reticular ER morphologies (Fig....
(b) Detectability of cancer marker proteins in “x” cell states as a function of the log-transformed number of matching spectral counts (x = 1–12 cell states corresponding to the G1/S cell cycle stages and nuclear/cytoplasmic fractions generated from the MCF7, MCF10 and SKBR3 cells...
The immunohistochemical evidence of cytokeratin AE1/AE3 seems to be the most sensitive marker15. There are different theories how such biphasic tumours develop. Previous studies have shown that the mesenchymal and epithelial components might be of monoclonal origin16,17. Hence, the theory that ...