This drug was also found to facilitate reversal learning in rats, and this effect was accompanied by a significant increase of 5-HT levels in the brain. The results of investigations into the actions of LSD 25 on single neurones in the brain stem, using the technique of microiontophoresis ...
In contrast, nothing is known about NTZ's mode of action on the nematodes, which is a limitation for its clinical use to cure parasitic roundworms. Finding the mode of action of a drug is important for three important reasons: (1) this knowledge can be used to enhance the efficacy of ...
n.1.(Medicine, Biochemistry)The mechanism{2} by which a pharmacologically active substance produces an effect on a living organism or in a biochemical system; as, themechanism of actionof actinomycin involves its binding to DNA. The mechanism of action is usually considered to include an identifi...
The biological activity of a drug determined in vitro (e.g., the minimal inhibitory concentration) is a parameter decisive in determining the effect of antituberculotics on mycobacteria in a disease focus. Knowledge of the mode of action yields further therapeutically important information, such as...
Discovery of drug mode of action and drug repositioning from transcriptional responses. A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous a... - 《Proceedings of the National Academy of ...
药物设计是一门科学,一门技术,更是一门多学科融合的艺术。众所周知,发明是一种创造性行为的产物,而发现则是对已知世界的探索。药物设计紧紧围绕发明和发现两个过程,旨在建立一套来源于现有知识和技术但又高于现有知识和技术的方法。而且,从事药物设计的科学家的创造性
Drug Mode of Action Similarity and Clustering WANG Zhi-Gang CHEN Xin XIE Li-Fang YANG Xiao-LinZHANG Zheng-Guo 10. 3969/j. issn. 0258-8021. 2011.06. 002 2011-07-302011-09-10 国家科技支撑计划( 2008BAI52B02);国家科技部科技基础性工作专项(2006FY110300);国家自然科学基金(30800241) ...
Classification of Drugs Drugs can be classified mainly based on the following criteria: Pharmacological Effect Chemical Structure Drug Action Molecular Targets Based on Pharmacological Effect– Based on the action of drugs on our body, they are classified based on their therapeutic actions. Such as ant...
Sodium salicylate decreased cyclic 3′,5′-AMP levels in the presence and absence of PGE 1 . However, GAG secretion was reduced only in cells with elevated cyclic 3′,5′-AMP levels, since the drug activated cyclic 3′,5′-AMP-independent protein kinase activity, thus presumably precluding ...
Chapter 6 - Antimalarial drugs: discovery, mechanism of action, and drug resistance Summary Intermittent preventive treatment in infants (IPTi) is an effective and safe malaria control strategy. However, it remains unclear what antimalaria... GP Yadav,AP Arukha,Y Kothapalli,... - Elsevier Inc...