13、(1)本发明首次提供了pad2在调控mo-mdscs细胞分化中的应用,本发明首先通过qrt-pcr、western blot、共聚焦显微镜观察等方式检测了cia小鼠脾脏和mo-mdscs中5种同工酶(pad1、pad2、pad3、pad4和pad6)的mrna表达水平,发现mo-mdscs细胞内表达pad2和pad4,本发明进一步敲减mo-mdscs细胞中pad2或pad4的表达后,...
In conclusion, Mo-MDSCs are pivotal players in CRC-related immunosuppression and may be associated with the risk of tumor recurrence after surgery.doi:10.1016/j.tranon.2022.101346Izabela.SiemińskaDepartment of Clinical Immunology, Institute of Paediatrics, Jagiellonian University Medical College, Wie...
Mechanistically, CCL7 secreted by Mo-MDSCs bound with membrane protein CCR2 of micro-metastatic cells and then stimulated the JAK/STAT3 pathway to activate the dormant cells. Low-dose administration of CCL7 and MDSCs inhibitors in vivo could significantly maintain the CRC metastatic cells dormant ...
Mo-MDSCs are enriched in a subpopulation of patients with locoregional recurrence or metastatic breast cancer.Caroline, BergenfelzAnnaMaria, LarssonKristoffer, von StedingkSofia, GruvbergerSaalKristina, AaltonenSara, JanssonHelena, JernströmHelena, Janols...
034 Dysregulation of VISTA expression and functionality in psoriatic monocytes and Mo-MDSCsdoi:10.1016/J.JID.2021.02.050K. OhkoT.S. McCormickA.B. YoungL. WangK.D. CooperElsevier BVJournal of Investigative Dermatology
Flow cytometry analysis of circulating Gr-MDSCs and Mo-MDSCs cells in PB from HD and CML patients at diagnosis (D) and during IM therapy.Cesarina, GiallongoNunziatina, ParrinelloDaniele, TibulloPiera, La CavaAlessandra, RomanoAnnalisa, Chi...