MNX1-AS1在头颈鳞癌组织中的表达情况,结合头颈鳞癌患者的临床病理参数进行分析,进一步通过细胞功能实验明确LncRNA MNX1-AS1在头颈鳞癌细胞系中的作用,从而为头颈鳞癌的诊断,治疗和预后提供新的靶点.方法:首先,搜集查找TCGA(The cancer genome atlas)数据库中的头颈肿瘤转录组的测序数据,分析LncRNA MNX1-AS1在头颈鳞癌...
MNX1-AS1 Cancer Oncogenic Biomarker 1. Introduction Cancers become a serious threat to human health since of its characteristic of concealment and recurrence [1], [2]. In 2020, there were 606,520 deaths and 18,065,090 new cancer cases in the United States, respectively [3]. Therefore, fin...
ＡＫＴ㊁ｐ－ｍＴＯＲ蛋白表达水平显著降低(Ｐ<０.０５)ꎮ结论:ｌｎｃＲＮＡＭＮＸ１－ＡＳ１在ＮＳＣＬＣ中表达水平升高ꎬ可能通过激活ＰＩ３Ｋ/ＡＫＴ通路影响ＮＳＣＬＣ细胞的增殖㊁迁移㊁侵袭ꎬ促进ＮＳＣＬＣ的发生发展ꎮʌ关键词ɔ㊀非小细胞肺癌ꎻ㊀长链非编码ＲＮＡＭＮＸ１－...
Long non-coding RNAs (lncRNAs) have extremely complex roles in the progression of intrahepatic cholangiocarcinoma (ICC) and remain to be elucidated. By cytological and animal model experiments, this study demonstrated that the expression of lncRNA MNX1-A
摘要: 目的 研究长链非编码RNA运动神经元和胰腺同源盒1反义RNA1(lncRNA MNX1-AS1)在结直肠癌组织中的表达及其临床意义,并探讨MNX1-AS1在结直肠癌中发挥的生物学功能.方法 采用实时荧光定量PCR(qRT-PCR)检测MNX1-AS1在60例结直肠癌组织和癌旁组织中的表达水平,并分析结直肠癌组织中MNX... 查看全部>> ...
目的研究长链非编码RNA运动神经元和胰腺同源盒1反义RNA1(lncRNA MNX1-AS1)在结直肠癌组织中的表达及其临床意义,并探讨MNX1-AS1在结直肠癌中发挥的生物学功能.方法采用实时荧光定量PCR(qRT-PCR)检测MNX1-AS1在60例结直肠癌组织和癌旁组织中的表达水平,并分析结直肠癌组织中MNX1-AS1的表达水平与患者临床病理参数...
Besides, knockdown of MNX1-AS1 remarkably down-regulated the mRNA and protein levels of insulin-like growth factor 2 (IGF2). Furthermore, IGF2 expression was positively correlated with MNX1-AS1 expression in ESCC tissues.MNX1-AS1 serves as a potential oncogene in ESCC, which can significantly...
Moreover, while MNX1-AS1 expression is driven by c-Myc, its actions associated with PKM2 were shown to be downstream and independent of c-Myc.#Given the status of MNX1-AS1 as a pan-cancer upregulated lncRNA, this implicitly highlights the potential of targeting MNX1-AS1 to selectively ...
Furthermore, we conducted quantitative real‐time polymerase chain reaction, and confirmed that the expression of MNX1‐AS1 was definitely higher in lung adenocarcinoma tissue samples, but not in lung squamous cell carcinoma tissue samples. In addition, high MNX1‐AS1 expression was found to be ...