MNX1-AS1在头颈鳞癌组织中的表达情况,结合头颈鳞癌患者的临床病理参数进行分析,进一步通过细胞功能实验明确LncRNA MNX1-AS1在头颈鳞癌细胞系中的作用,从而为头颈鳞癌的诊断,治疗和预后提供新的靶点.方法:首先,搜集查找TCGA(The cancer genome atlas)数据库中的头颈肿瘤转录组的测序数据,分析LncRNA MNX1-AS1在头颈鳞癌...
Aberrant expression of MNX1-AS1 closely correlates with clinicopathological parameters. such as lymphatic metastasis, tumor size, tumor stage, OS and DFS. Thus, MNX1-AS1 can be used as a diagnostic and prognostic biomarker or even a therapeutic prognostic target. This article reviews its function,...
Fig. 1: MNX1-AS1 and MNX1 were highly expressed in ICC tissues and cholangiocarcinoma cell lines. Full size image MNX1-AS1 facilitates the expression of MNX1 protein by recruiting transcription factors c-Myc and MAZ Fig. 2: MNX1-AS1 facilitates the expression of MNX1 via c-Myc and MAZ....
MNX1-AS1在头颈鳞癌组织中的表达情况,结合头颈鳞癌患者的临床病理参数进行分析,进一步通过细胞功能实验明确LncRNA MNX1-AS1在头颈鳞癌细胞系中的作用,从而为头颈鳞癌的诊断,治疗和预后提供新的靶点.方法:首先,搜集查找TCGA(The cancer genome atlas)数据库中的头颈肿瘤转录组的测序数据,分析LncRNA MNX1-AS1在头颈鳞癌...
SH3域结合谷氨酸丰富蛋白样蛋白3喉癌迁移目的分析长链非编码RNA MNX1反义RNA 1(MNX1-AS1)调节miR-744-5p/SH3域结合谷氨酸丰富蛋白样蛋白3(SH3BGRL3)对喉癌细胞生长,迁移的影响.方法构建敲低MNX1-AS1稳定转染Hep-2细胞(sh NC组和sh MNX1-AS1组),构建miR-744-5p瞬时转染细胞系(NC mimics组,miR-744-5p ...
Besides, knockdown of MNX1-AS1 remarkably down-regulated the mRNA and protein levels of insulin-like growth factor 2 (IGF2). Furthermore, IGF2 expression was positively correlated with MNX1-AS1 expression in ESCC tissues. CONCLUSIONS: MNX1-AS1 serves as a potential oncogene in ESCC, which ...
Furthermore, we conducted quantitative real‐time polymerase chain reaction, and confirmed that the expression of MNX1‐AS1 was definitely higher in lung adenocarcinoma tissue samples, but not in lung squamous cell carcinoma tissue samples. In addition, high MNX1‐AS1 expression was found to be ...
MNX1-AS1 was signifcantly upregulated in ESCC tissues. It was conformed that high MNX1-AS1 expression was associated with ESCC lymph node metastasis. Moreover, we found that knockdown of MNX1-AS1 apparently suppressed the cell proliferation, migration, and invasion capacity. Flow cytometry ...
DNA3.1组比较,红凉伞提取物+pc DNA3.1-MNX1-AS1组细胞增殖抑制率,凋亡率及P21,Caspase-3,E-cadherin表达水平均降低(P<0.05),细胞克隆形成数,迁移,侵袭细胞数及MNX1-AS1,MMP-2表达水平均升高(P<0.05).结论:红凉伞提取物可抑制乳腺癌细胞MDA-MB-453增殖,迁移和侵袭,促进细胞凋亡,其机制可能与MNX1-AS1有关....