21o inhibits the growth of myeloid leukemia K562 and MOLM-13 cells with GI50's of 2.1 and 1.2 mu M, respectively. 21o decreases the levels of p-eIF4E and p-4EBP1, the downstream products of MNKs and PIMs, as well as cap-dependent proteins c-myc, cyclin D1, and Mcl-1. 21o ...
And the expression levels of MNK1, ERK1/2 and pERK1/2 are not affected by compound 12dj incubation in SUNE-1 and 786-O cells. In summary, our works suggested that these novel 4-aniline-thieno[2,3-d]pyrimidine based MNK1 inhibitors might be attractive lead compounds for targeted ...
interaction.CellularmechanisticstudiesonMV-4-11cellswithleads7a,8eand8frevealthattheyare abletodown-regulatethephosphorylatedeIF4E,Mcl-1andcyclinD1,andinduceapoptosis. ©2015ElsevierMassonSAS.Allrightsreserved. 1.Introduction Dysregulationofproteinsynthesisisimplicatedinthepro- gressionofvariouspathologies,mostno...
And the expression levels of MNK1, ERK1/2 and pERK1/2 are not affected by compound 12dj incubation in SUNE-1 and 786-O cells. In summary, our works suggested that these novel 4-aniline-thieno[2,3-d]pyrimidine based MNK1 inhibitors might be attractive lead compounds for targeted ...
Bilirubin Restrains the Anticancer Effects of Vemurafenib on BRAF-Mutant Melanoma Cells via ERK-MNK1 Signalingdoi:10.2139/ssrn.3810033bilirubinvemurafenibERKMNK1BRAF-mutant melanomaBackground: Melanoma, the most threatening cancer in the skin, has been considered to be driven by the carcinogenic RAF-...
As nucleoli are increased in number and volume in cancer cells, they are used for diagnosis and prognostication. Nucleolar information is, in fact, critical to grade preinvasive and invasive breast cancers. We tested the relation...
H. Tung
Cellular mechanistic studies on MV-4-11 cells with leads 7a, 8e and 8f reveal that they are able to down-regulate the phosphorylated eIF4E, Mcl-1 and cyclin D1, and induce apoptosis.MingfengYuPengLiSunitaK.C.BasnetMalikaKumarasiriSarah...
However, this compound in combination with our in-house CDK4/6 inhibitor 83 did not show a synergistic effect in A2780 ovarian cancer cells, suggesting that caution be exercised in the selection of an agent to be combined with an Mnk inhibitor. Copyright 2019 Elsevier Ltd. All rights ...
Peripheral blood mononuclear cells were cultured to obtain two types of endothelial progenitor cells from the same donors. MTT and cell adhesion assays were performed to evaluate cell viability and the adhesion of THP-1 cells to human umbilical...