Sorafenib is one of FLT3-ITD inhibitors used in clinic. Using FLT3-ITD AML MOLM-13 cell line, we established a sorafenib resistant subclone MOLM-13/Sor, explored the resistance mechanism and revealed the overactivated mTOR signaling. MNK as one of the alternative mTOR signaling pathways is ...
TMD8Function assay0.01, 0.1, 1, 3 and 10 μM2 hpotent dose-dependent inhibition of eIF4E Ser209 phosphorylation29526098 TMD8Proliferation assay12 hIC50=2.53 μM30824167 MV4-11Proliferation assay12 hIC50=14.49 μM30824167 Click to View More Cell Line Experimental Data ...
TNF-α: Tumor necrosis factor-α; IL: Interleukin; RANTES: Regulated upon activation normal T cell expressed and presumably secreted; TGF: Transforming growth factor; MMP3: Matrix metalloprotease 3; IRES: Internal ribosome entry sites; IFNs: Interferons. ...
j, Translation efficiency (polysomal mRNA expression/ total mRNA expression) of HGF, SPP1, BGN, ISG15 and PDGFB upon 500 nM eFT508 treatment and PDCD4 rescue in human PC3 prostate cancer cell line (n = 3 independent experiments). Data are mean ± SD. Statistical analysis between all ...
Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol. 2007;27:7405–13. Article CAS PubMed PubMed Central Google Scholar Wen Q, Wang WY, Luo JD, Chu SZ, Chen LJ, ...
Human HEK293T cells were grown in 6-well plates in DMEM supplemented with 10% fetal bovine serum at a cell density of 3 × 105 cells/well and transfected using Lipofectamine 2000 (Invitrogen). After 24 h of transfection, the medium was removed and the cells were washed twice with ice-col...
2.3. Cell Growth Assays Cells were seeded in 96-well plates at 3 × 103 cells/well in 200 μL 2.5% FBS complete medium. Prior to incubation at 37 °C, the plated cells were left at room temperature (RT) for 1 h, to distribute evenly. The compounds were added 24 h later (2 μL...
The SCRIB gene (SCRIBBLE, SCRB1; OMIM# 607733) encodes for a protein named Scribble (Scrib), which is key in many developmental processes including cell proliferation, migration and polarity [3]. Scrib is known for its involvement in planar cell polarity signaling that regulates embryonic and po...
3) Gastric cancer cell line 胃癌细胞株 1. Expression of HIF-1α and VEGF in human gastric cancer cell line BGC-823 which induced by extrinsic PGE_2; PGE_2诱导胃癌细胞株BGC-823 HIF-1α、VEGF表达 2. Effect of hyperthermia on telomerase activity and genes expression in human gastric ...
5. 24Hours service :Cell+86-13915707468 Zhangjiagang Jorbin Machinery Co., Ltd. Contact Supplier Click here to contact the supplier through an inquiry. Chat Find Similar Products By Category Supplier HomepageProductsplastic granulation lineSingle screw extruderPVC HDPE...