MMTV-PyMT细胞可在C57BL/6雌性小鼠乳腺脂肪垫成瘤并生长,但未见远处内脏转移.该细胞在细胞学和组织学中的分子分型皆为HER2过表达亚型,肿瘤组织中Ki-67阳性表达率为34%.结论:成功构建得到可体外稳定传代并具有体内成瘤能力的HER2过表达分子亚型小鼠乳腺癌细胞系,该细胞可作为HER2过表达亚型乳腺癌体内,外实验研究的...
The Oncotype DX 21-gene Recurrence Score assay is used in clinical practice for guiding adjuvant chemotherapy treatment decisions for women with early-stage, estrogen receptor (ER)-positive, HER2-negative breast cancer [1,2,3,4]. The Oncotype DX assay quantifies the expression of 16 genes asso...
MMTV-PyMT tumors lose expression of ERα and PR as they progress [14], and though MMTV-PyMT primary tumors are reported to express HER2 [14], levels are low compared to those in human HER2+ cell lines that have amplified HER2 (data not shown). Notably, gene expression profiling clustered...