102]. In 2017, both pembrolizumab and nivolumab received FDA approval for use in dMMR/MSI-H mCRC. The recommendations for CRC immunotherapy mainly apply to dMMR/MSI-H patients. Updated results from the CheckMate142 study demonstrated a 12-month PFS of 77...
As known, IFN-β-induced adaptive responses mostly depend on IFN-inducible GTPases, which include myxovirus resistance proteins, immunity-related GTPases, the GBPs, and the very large IFN-inducible GTPases [30]. Among them, we noticed that GBP2 had a relatively high basic expression and ...
Therefore, dynamic observation of changes in the number of lymphocytes can not only reveal the state of the acquired immune response, but also help evaluate the balance between innate immunity and acquired immunity. As important immune regulatory cells, Tregs participate in the process of sepsis-...
IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol. 2014;31:31–7. Article CAS PubMed Google Scholar Roussel L, Erard M, Cayrol C, Girard JP. Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-...
Results We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse model. Infiltration of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI, aggravati...
[77]. Aside from IgG+ and IgA+ MBC populations, most memory immune cell subsets show a general decline in serological immunity over time. More significantly, immunological degradation rates most likely stabilise over time, approaching homeostatic maintenance values. For SARS-CoV-2 infections, however...
Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response. J Hematol Oncol. 2021;14(1):98. PubMed PubMed Central Google Scholar Gibson GJ, Loddenkemper R, Lundbäck B, Sibille Y. Respiratory health and disease in Europe: the new European Lung ...
sGP, is soluble and can be secreted in large quantities by infected cells and inhibit the early activation of neutrophils by binding to CD16b leading to suppression of anti-viral innate immunity. sGP also facilitates EBOV replication [33]. This partially explains why EBOV can spread rapidly in...
Similar to iron, zinc is also an important trace element required by the human body and plays an important role in many physiological activities (such as growth, immunity, and wound healing) [207,208]. It is reported that about 85% of zinc is present in muscles and bones, so zinc is ...
regulation analysis based on scRNA-seq, a rigorous judgment on the inferred results needs to be made, due to the complexity of transcriptional regulation and the insufficient information provided by scRNA-seq data. Performing validation experiments may make the inferred results more solid [253,254]....