laryngeal cancerclinical significance目的探讨基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-14(MMP-14)在喉癌中的表达及意义。方法应用流式细胞术检测40例喉癌组织、28例癌旁组织及15例喉部正常粘膜组织中MMP-2、MMP-14的表达。结果MMP-14、MMP-2蛋白在喉癌组织中的表达量均高于正常粘膜组织(P〈0.05)。在喉癌组织...
Thus,MMP-14andinvadopodiahavecriticalrolesintumorigenesisandcancerprogression.Keywords: MMP-14;Invadopodia;Cancer;Invasionandmetastasis 虽然近年来肿瘤综合治疗水平有所提高,但是如何提高肿瘤患者生存率和生活质量一直都是临床医生亟待解决的问题。 肿瘤细胞发生侵袭和转移是导致肿瘤患者死亡的关键,这些过程依赖于 ECM的...
Tiam1和MMP14在宫颈癌中表达临床意义 [摘要] 目的 检测Tiam1和MMP-14在宫颈鳞癌、宫颈上皮内瘤变和正常宫颈中的表达,了解其在宫颈鳞癌的发生发展以及浸润转移方面的作用。 方法 收集某院病理科2010年6月～2012年6月手术切除宫颈鳞癌标本100例,宫颈上皮内瘤变30例,正常宫颈10例。采用免疫组化二步法检测两者在宫颈...
7.RheeJS,CoussensLM.RECKing MMP function:imp lications for cancer development[J].Trends Cell Boil,2002;12(5):209-211 8.高进,章静波。癌的侵袭和转移基础与临床.北京:科学出版社.2003.5;86 9. vanWartHE,BirkedalHH.Thecysteineswitch:aprincipleofregulationofmetalloproteinaseactivitywithpotentialapplieabilit...
ObjectiveTo detect the levels of T lymphocyte subsets, vascular endothelial growth factor (VEGF), metalloproteinase-14 (MMP-14) in patients with primary liver cancer (HCC) after radiofrequency ablation (RFA), to evaluate the clinical evaluation value of the above indexes in residual carcinoma. Meth...
摘要:肺癌5年生存率低,侵润和转移是导致其死亡的主要原因.探讨MMP14(matrix mettallo proteinase14)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达,及其与浸润转移和预后的关系.通过采用免疫组化检测92例NSCLC组织及25例癌旁正常组织中MMP14蛋白的表达,并分析其与临床病理学特征及预后的关系.免疫...
[4]Lee KH,Kim JR.Kiss1 suppresses MMP9 expression by activating p38 MAP kinase in human stomach cancer[J].Oncol Res,2009,18(2-3):107-116. [5]Klein G,Vellenga E,Fraaije MW,et al.The possible role of matrixmetalloproteinase (MMP)2 and VIP免费下载 收藏 分享 赏 0...
In order to evaluate the role of MMP-14 in ovarian cancer, a systematic review was conducted. In March 2020, a search in Pubmed was performed with MMP-14 and ovarian cancer as search terms. After exclusion of the references not on MMP-14 or ovarian cance
At last, the high expression and bad prognostic effects of MMP14 and PKM2 in pancreatic cancer were validated using tissue microarray. Overall, the genomic alterations and associated transcriptomic profiling analysis suggested new prognostic makers of MMP14 and PKM2 in pancreatic cancer. ...
cancer.The expression.of TIMP一2wascorrelated tosizeofulcer(P<O.011in gastriculcer bue notcorrelatedtoulcer position (4)There was positive correlationbetweenthe expression ofMMP一2and MMP一14in gastriccancer(r;=0.447,P>O.05).Theexpression ...