单倍型基因分析显示,SAP患者MMP-2基因rs243865 C>T和rs2285053 C>T位点的单倍型CC和CT与增加UTI有效性相关(OR = 0.501,95%CI = 0.316-0.797,p =0.003; OR = 0.138,95%CI = 0.035-0.553,p =0 .001),且MMP-9基因 rs3918...
摘要 目的观察基质金属蛋白酶-19(matrix metalloproteinase-19,MMP-19)在结直肠腺癌组织中的表达及意义.方法采用免疫组化法检测71例结直肠腺癌,32例结直肠腺瘤和34例癌旁正常结肠黏膜组织中MMP-19的表... 关键词结直肠肿瘤 / 腺癌 / MMP-19 / 免疫组织...
We have previously discovered the implication of membrane-type 5-matrix metalloproteinase (MT5-MMP) in AD pathogenesis. Here we shed new light on pathogenic mechanisms by which MT5-MMP controls APP processing and the fate of amyloid beta peptide (Aβ) and its precursor C99. We found that MT5...