Particularly, the present invention relates to the suitable purposes as drug of novel prodrugs monomethyl fumarate (MMF), preferably in the systemic disease treated and/or prevented, autoimmune disease, inflammatory disease, such as multiple sclerosis and psoriasis.ALBRECHT Wolfgang...
MMF及其代谢物的药代动力学特征 ElbarbryFA,ShokerAS.Therapeuticdrugmeasurementofmycophenolicacidderivativesintransplantpatients[J].ClinicalBiochemistry,2007,40(11):752-64.2 MMF常见不良反应 MMF常见的不良反应 胃肠功能紊乱骨髓抑制机会性感染心血管系统毒性肿瘤 （1）MMF所致胃肠功能紊乱 霉酚酸酯在系统性硬化症中的...
April 23, 2004 (San Francisco) — Although a drug regimen including tacrolimus had an equivalent survival rate as two other regimens, it had the lowest incidence of rejection among heart transplant patients and the fewest adverse effects, researchers reported here at the annual meeting of the Inte...
MMF is an immunosuppressive drug frequently used for graft-versus-host disease (GVHD) prophylaxis and management. MMF-induced colitis is a known complication, however, details regarding its clinical manifestations, treatment options, and outcomes are less clear. Differentiating MMF-induced colitis from ...
Mycophenolate mofetil (MMF) is a novel immunosuppressive drug that shows promise in preventing the rejection of organ allografts and in the treatment of ongoing rejection. Orally administered MMF is hydrolyzed by esterases in the intestine and blood to release mycophenolic acid (MPA), a potent, sele...
In kidney transplantation, MMF is approved at a fixed dose of 2 Â 1000 mg per day in combination with CSA and steroids.12 Means of further improving the efficacy of MMF with therapeutic drug monitoring are under investigation. Typical side effects of MPA are infections, leucopaenia, anaemia...
4.Fujiyama, N., Miura, M., Kato, S.,et al.Involvement of carboxylesterase 1 and 2 in the hydrolysis of mycophenolate mofetil.Drug Metab. Dispos.38(12),2210-2217(2010). 5.Räisänen-Sokolowski, A., Vuoristo, P., Myllärniemi, M.,et al.Mycophenolate mofetil (MMF, RS-61443) inh...
For prevention and treatment of severe GvHD following HSCT, the immunosuppressive drug mycophenolate mofetil (MMF; Cellcept) and Ciclosporin A (CsA) may be administered [3]. MMF is a prodrug which is systemically metabolized to the active metabolite mycophenolic acid (MPA). MPA non-competitively in...
袁婷婷,张锐锋 - Evaluation & Analysis of Drug-Use in Hospitals of China 被引量: 0发表: 2019年 吗替麦考酚酯联合泼尼松治疗难治性狼疮性肾炎的疗效观察 目的: 观察吗替麦考酚酯(MMF)联合泼尼松治疗难治性狼疮性肾炎(LN)的疗效及不良反应. 方法: 对传统免疫抑制剂治疗无效或复发的42例LN患者,采用MM...
NMPA-Approved Drug Library Orally Active Compound Library FDA Approved & Pharmacopeial Drug Library Drug-Induced Liver Injury (DILI) Compound Library Drug Metabolite Library Rare Diseases Drug Library Children’s Drug Library 生物活性 Mycophenolate mofetil (RS 61443) is the morpholinoethylester prodrug of...