Phospho-MLKL (Ser345) (D6E3G) Rabbit mAb #37333 100 µl RIP3 (D4G2A) Rabbit mAb #95702 100 µl RIP (D94C12) XP® Rabbit mAb #3493 20 µl Product Information Product Usage Information ApplicationDilution Western Blotting 1:1000 Immunoprecipitation 1:50 Storage Supplied in 10...
1 mL x 10 mM (in DMSO) ¥ 441 现货 大包装 & 定制 TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向个人提供产品和服务。请您遵守承诺用途,不得违反法律法规规定用于任何其他用途。 实验操作小课堂 常见问题解答 问溶解度中写的“< 1 mg/mL refers to the slightly soluble or...
Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.For standard formulation of this product see product #26539 Storage Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use ...
supporting a systemic effect of necroptosis inhibition on inflammation. Proteomic analysis of liver tissues emphasizes the critical role of lipid and immune regulatory processes in maintaining liver homeostasis when Mlkl or Ripk3 is absent in aging liver. While Mlkl deletion did not affect the lifespa...
MLKL-IN-2;MLKL-IN-2, 10 mM in DMSO;N-[3-[6-(4-methylpiperazin-1-yl)pyridazin-3-yl]phenyl]naphthalene-2-carboxamide 中文名: MLKL抑制剂2 中文别名: MLKL抑制剂2;MLKL抑制剂2,10 MM DMSO 溶液 CBNumber: CB23454134 分子式: C26H25N5O 分子量: 423.5096 MOL File: 899759-16-1.mol ...
MLKL-IN-5 产品编号T73279Cas号2755872-58-1 MLKL-IN-5 是一种有效的MLKL 抑制剂,可介导细胞坏死性凋亡。 规格价格库存数量 25 mg ¥ 10,600 6-8周 50 mg ¥ 13,800 6-8周 100 mg ¥ 17,500 6-8周 大包装 & 定制 TargetMol 的所有产品仅用作科学研究或药证申报,不能被用于人体,我们不向...
(as well as certain types of apoptosis) through its kinase activity [4,5]. Whether RIPK1 kinase activity mediates apoptosis or necroptosis depends on the inactivation of caspase-8 activity, a negative regulator of necroptosis [6,7]. Necroptosis is implicated in a plethora of diseases ranging ...
Recently, necroptosis-independent functions of MLKL were unraveled in receptor internalization, ligand-receptor degradation, endosomal trafficking, extracellular vesicle formation, autophagy, nuclear functions, axon repair, neutrophil extracellular trap (NET) formation, and inflammasome regulation. Little is ...
We propose that membrane-associated MLKL10C2clusters accumulate around RIPK1-containing necrosomes in the cytosol during the effector phase of necroptosis (Fig.2b, g). These clusters resemble the previously described RIPK3-containing puncta that form during necroptosis6. We further propose that vesicl...
In plants, a two-layered immune mechanism comprising pathogen-associated molecular pattern (PAMP)-triggered immunity and effector-triggered immunity (ETI)1,2,3,4,5,6 effectively detects and combats pathogenic microbes. In many cases, ETI is initiated by intracellular nucleotide-binding leucine-rich ...