However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Therefore, we aimed to study the role of MLH1 in the sensitivity of human endometrial carcinoma cells to cisplatin.关键词: Endometrial carcinoma, siRNA-MLH1, ADV-MLH1, Cisplatin sensitivity, Individualized therapy ...
本发明公开了一种检测MLH1基因启动子甲基化的引物对,试剂盒及方法,所述引物对具有如SEQ ID NO:1和SEQ ID NO:2所示的碱基序列,检测方法是以待检测样品转化后的DNA作为模板,进行荧光定量PCR反应,收集荧光信号,绘制熔解曲线;判读待检测样品的熔解曲线.本发明的检测方法可以廉价,快速,灵敏的对MLH1基因启动子进行甲基化...
We have herein reported a pathogenic missense mutation c.199G>A(p.Gly67Arg)in exon 2 of MLH1 in patients with MTS.This mutation has been reported in patients with Lynch syndrome who have no skin tumors.However,we also found that some patients with MTS had no history of any internal ...