肠道屏障MLCK/pMLC2通路目的:探究熊胆粉对结肠炎的治疗作用及机制.方法:小鼠自由饮用含3%葡聚糖硫酸钠的水溶液诱导结肠炎模型,造模成功后给予不同剂量的熊胆粉溶液(150,300,600 mg/kg)连续7 d,进行小鼠疾病活动指数(DAI)评分;测量结肠长度;HE染色观察结肠病理学变化;阿尔新蓝染色观察黏蛋白含量;FITC-葡聚糖检测肠...
背景与目的 :肠上皮紧密连接失调和上皮损伤导致上皮屏障破坏,促使炎症性肠病(IBD)的发生发展.本实验建立溃疡性结肠炎(UC)小鼠模型,探讨汉黄芩苷对肠上皮紧密连接以及MLCK/pMLC2信号通路的影响,进一步证明汉黄芩苷能够通过抑制MLCK/pMLC2信号通路修复肠上皮紧密连接,从而维持肠上皮屏障的完整性达到治疗IBD的目的.方法 :...
肠道屏障MLCK/pMLC2通路目的:探究熊胆粉对结肠炎的治疗作用及机制.方法:小鼠自由饮用含3%葡聚糖硫酸钠的水溶液诱导结肠炎模型,造模成功后给予不同剂量的熊胆粉溶液(150,300,600 mg/kg)连续7 d,进行小鼠疾病活动指数(DAI)评分;测量结肠长度;HE染色观察结肠病理学变化;阿尔新蓝染色观察黏蛋白含量;FITC-葡聚糖检测肠...
GLP-2 prevented the LPS-induced increase in the expression of MLCK dose-dependently and the increase in pMLC levels in the duodenum, jejunum, and ileum. To assess further the protective effect of GLP-2 on LPS-induced intestinal barrier injury after weaning and its possible mechanism, an in ...
Helicobacter hepaticus; CdtB; colonic mucosal barrier; tight junction; MLCK; pMLC21. Introduction Members of the genus Helicobacter have been reported in a wide range of animals, and they have been identified to infect numerous sites, including the stomach, small intestine, large intestine, liver...
Helicobacter hepaticus; CdtB; colonic mucosal barrier; tight junction; MLCK; pMLC21. Introduction Members of the genus Helicobacter have been reported in a wide range of animals, and they have been identified to infect numerous sites, including the stomach, small intestine, large intestine, liver...