However, chronic stress can lead to altered levels of HPA axis hormones and failure to response to stress ultimately results in negative impacts on cellular physiology. Further, chronic stress may produce physiological alterations that exceed the adaptability of mitochondria, inducing a condition termed ...
Our results reveal how loss of MITF regulates mitotic fidelity, and through defective replication and repair induces DNA damage, ultimately ending in cellular senescence. These findings reveal a lineage-specific control of DNA replication and mitosis by MITF, providing new avenues for therapeutic ...
MitosisMeiosis有丝分裂 减数分裂 Howdoorganismsgetfromonecelltobillionsortrillions???CELLDIVISION!!Howdoorganismsrepairthemselves?CELLDIVISION!!Whathappensifcelldivisionisuncontrolled?Somethingundesirable!Forexample,melanoma,atypeofskincancercausedbyuncontrolledgrowthofmelanocytes.CellDivision Cellularreproductionisa...
”In cell biology, mitosis is a part of what is called thecell cycle. The cell cycle, sometimes called the cell-division cycle, is the series of events that occur in a cell that lead to duplication of that cell’s DNA and, ultimately, the creation of new cells.During mitosis, the cel...
(taxanes).24–27Paclitaxel is one of the most widely utilized anticancer agents, with clinical efficacy in a wide range of cancers. Paclitaxel disrupts normal microtubule function, arresting mitosis at the metaphase/anaphase boundary, and interfering with several critical interphase functions ultimately ...
During division, these intra nuclear kinetochores undergo a characteristic sequence of morphological changes, ultimately becoming inserted in openings of the nuclear envelope and making contact with extranuclear spindle microtubules. The more detailed description of this division which follows is based on ...
CENP-E is a kinesin-like protein that binds to kinetochores through the early stages of mitosis, but after initiation of anaphase, it relocalizes to the overlapping microtubules in the midzone, ultimately concentrating in the developing midbody. By immunoblotting of cells separated at various posi...
Some plants can reproduce asexually (by mitosis, they produce structures that can break apart from the parent plant and sprout as an independent plant with the same genetic composition as the parent plant) and sexually (by meiosis, ultimately producing ma...
The juxtaposition of the HOX11 gene downstream of either the TCRα/δ or TCRβ regulatory elements results in aberrant expression of the homeobox gene in T lymphocytes, a cell type in which it is not typically expressed, leading to T lymphocyte transformation and ultimately, the development of ...
Mechanistically, COX6C-induced mitochondrial deficiency stimulates ROS accumulation and activates AMPK pathway, then leading to abnormality in spindle formation and chromosome segregation, activating spindle assemble checkpoint, causing mitotic arrest, and ultimately inducing cell apoptosis. Collectively, we ...